Haritha S, Rajagopalan G
Department of Obstetrics & Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Int J Gynaecol Obstet. 2003 Jun;81(3):287-92. doi: 10.1016/s0020-7292(02)00404-6.
To evaluate follicular growth, endometrial thickness, and serum estradiol levels in spontaneous cycles and cycles induced by clomiphene citrate (CC).
A 2-year prospective study of spontaneous cycle followed by a CC-induced cycle to compare paired data. Twenty couples with unexplained infertility were recruited from the Infertility Clinic of the Jawaharlal Institute of Postgraduate Medical Education and Research. An oral dose of 150 mg of CC was administered on days 5 through 9 of the CC-induced cycle. Each woman was evaluated using transvaginal sonography and serum estradiol level estimation from day 10 of the menstrual cycle until ovulation. Results were analyzed using the paired t-test.
The leading follicular diameter was significantly larger, endometrial thickness was significantly decreased, and serum estradiol levels were significantly higher in the follicular phase of CC-induced cycles.
Clomiphene citrate-induced cycles showed different follicular, endometrial growth patterns, and serum estradiol levels compared with spontaneous cycles.
评估自然周期以及枸橼酸氯米芬（CC）诱导周期中的卵泡生长、子宫内膜厚度和血清雌二醇水平。
进行一项为期2年的前瞻性研究，先观察自然周期，随后观察CC诱导周期以比较配对数据。从贾瓦哈拉尔研究生医学教育与研究学院不孕症诊所招募了20对不明原因不孕症夫妇。在CC诱导周期的第5至9天口服150 mg CC。从月经周期第10天直至排卵，对每位女性进行经阴道超声检查和血清雌二醇水平测定。结果采用配对t检验进行分析。
在CC诱导周期的卵泡期，主导卵泡直径显著更大，子宫内膜厚度显著降低，血清雌二醇水平显著更高。
与自然周期相比，枸橼酸氯米芬诱导周期表现出不同的卵泡、子宫内膜生长模式和血清雌二醇水平。
