Tórtora J L, Selinke E, Castellano M A
Acta Anat (Basel). 1975;91(3):462-6. doi: 10.1159/000144406.
New Hampshire eggs were injected with iproniazid into the yolk sac at day 2 of incubation by means of a tiny hole in the shell. A control group was injected with normal saline and a second group was left unopened. Iproniazid in the doses we used proved to be lethal for approximately 50% of the chick embryos, while we cannot demonstrate other developmental alterations, either in the macroscopical or in the serial histological study.
在孵化第2天，通过在蛋壳上钻一个小孔，将异烟酰异丙肼注入新罕布什尔鸡蛋的卵黄囊中。一组对照组注射生理盐水，另一组不做处理。我们使用的剂量的异烟酰异丙肼被证明对约50%的鸡胚胎具有致死性，而在大体或系列组织学研究中，我们均未发现其他发育异常。
