Djavan B, Waldert M, Seitz C, Marberger M
Department of Urology, University of Vienna, Austria.
World J Urol. 2001 Aug;19(4):225-33. doi: 10.1007/s003450100220.
Prostate cancer is one of the most common malignant tumors in Western countries. The etiology of prostate cancer is currently unknown, but it has been suggested that growth factor abnormalities may be involved in initiation and progression of this disease. Insulin-like growth factors (IGFs), including IGF-1 and IGF-2, are mitogenic peptides involved in the regulation of cell proliferation, differentiation and apoptosis. Studies have shown that IGFs are potent mitogens for a variety of cancer cells including prostate cancer since they stimulate cancer cell growth and suppress programmed cell death. This review outlines elements of IGF pathophysiology, reviews recent evidence that circulating IGF-1 levels are related to prostate cancer risk and discusses the clinical implications of these lines of research with respect to prevention and treatment.
前列腺癌是西方国家最常见的恶性肿瘤之一。目前前列腺癌的病因尚不清楚，但有人提出生长因子异常可能参与了该疾病的发生和发展。胰岛素样生长因子（IGFs），包括IGF-1和IGF-2，是参与细胞增殖、分化和凋亡调节的促有丝分裂肽。研究表明，IGFs是包括前列腺癌在内的多种癌细胞的强效促有丝分裂原，因为它们能刺激癌细胞生长并抑制程序性细胞死亡。本综述概述了IGF病理生理学的要素，回顾了循环IGF-1水平与前列腺癌风险相关的最新证据，并讨论了这些研究方向在预防和治疗方面的临床意义。
