Pollak M, Beamer W, Zhang J C
Jewish General Hospital-McGill University, Montreal, Quebec, Canada.
Cancer Metastasis Rev. 1998;17(4):383-90. doi: 10.1023/a:1006154108619.
Converging data from epidemiological and biological research implicate insulin-like growth factor (IGF) physiology in the regulation of prostate epithelial cell proliferation and in the pathophysiology of prostate cancer. This review (1) outlines elements of IGF physiology, (2) reviews recent evidence that circulating IGF-I level is related to risk of prostate cancer, (3) provides a hypothesis concerning the biological basis for the relationship between IGF-I level and risk of prostate cancer, (4) discusses IGF-I physiology in the context of neoplastic progression of prostate cancer, and (5) discusses clinical implications of these lines of research with respect to prevention and treatment.
来自流行病学和生物学研究的汇聚数据表明，胰岛素样生长因子（IGF）生理机能在前列腺上皮细胞增殖调节及前列腺癌病理生理学中发挥作用。本综述：（1）概述IGF生理机能的要素；（2）回顾循环IGF-I水平与前列腺癌风险相关的最新证据；（3）提出关于IGF-I水平与前列腺癌风险之间关系的生物学基础的假说；（4）在前列腺癌肿瘤进展的背景下讨论IGF-I生理机能；（5）讨论这些研究方向在预防和治疗方面的临床意义。
