Nakayama I, Tsuda N, Muta H, Fujii H, Tsuji K, Matsuo T, Takahara O
Acta Pathol Jpn. 1975 May;25(3):251-68. doi: 10.1111/j.1440-1827.1975.tb03256.x.
Two cases of Ewing's sarcoma and two neuroblastoma, rosette forming and round cell type, were studied electron microscopically and their fine structures were compared. The neoplastic cells of Ewing's sarcoma were characterized by aggregated glycogen particles in the cytoplasm. They had pseudopod-like cytoplasmic processes having tight junctions, which never contained microtubules or mitochondria. Ewing's sarcoma cells exhibited several stages of cell maturation and some mature cells possessed a large amount of smooth and rough endoplasmic reticulum, large Golgi complexes and numerous phagosomes containing glycogen particles as well as cytoplasmic organelles. The neoplastic cells of neuroblastoma, rosette forming type, were characterized by synaptic junctions and numerous cytoplasmic processes with production of neurites containing microtubules, neurofibrils, mitochondria and a few catecholamine granules. A few cytoplasmic processes containing mitochondria were observed even in the round cell type.
对两例尤因肉瘤以及两例呈菊形团形成型和圆形细胞型的神经母细胞瘤进行了电镜研究，并比较了它们的精细结构。尤因肉瘤的肿瘤细胞以胞质内聚集的糖原颗粒为特征。它们具有带有紧密连接的伪足样胞质突起，这些突起从不含有微管或线粒体。尤因肉瘤细胞表现出细胞成熟的几个阶段，一些成熟细胞拥有大量的滑面和粗面内质网、大型高尔基体复合物以及含有糖原颗粒和胞质细胞器的众多吞噬体。呈菊形团形成型的神经母细胞瘤的肿瘤细胞以突触连接和众多带有产生含有微管、神经原纤维、线粒体和一些儿茶酚胺颗粒的神经突的胞质突起为特征。即使在圆形细胞型中也观察到了一些含有线粒体的胞质突起。
