Penrod L E, Allen J B, Cabacungan L R
Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine. PA 15213, USA.
Arch Phys Med Rehabil. 2001 Sep;82(9):1270-3. doi: 10.1053/apmr.2001.23848.
This study investigated whether an interaction between common enteral feeding products and warfarin exists. Two clinical cases of apparent interaction spurred a supporting in vitro study. Both the clinical cases and the in vitro study showed that several enteral feeding products bind warfarin, reducing the bioavailability of the drug. The binding appears to occur between warfarin and the protein component of the feeding product. This clinically important interaction is likely when warfarin and enteral feeding products are used concurrently. Clinicians should be aware of this potential interaction and monitor the therapy closely, particularly when enteral feeding is discontinued.
本研究调查了常见肠内营养产品与华法林之间是否存在相互作用。两例明显相互作用的临床病例促使开展了一项支持性的体外研究。临床病例和体外研究均表明，几种肠内营养产品会与华法林结合，降低该药物的生物利用度。这种结合似乎发生在华法林与营养产品的蛋白质成分之间。当华法林与肠内营养产品同时使用时，这种具有临床重要性的相互作用很可能会发生。临床医生应意识到这种潜在的相互作用，并密切监测治疗情况，尤其是在停止肠内营养时。
