Grant Paul
Department of Surgery, William Harvey Hospital, Ashford, United Kingdom.
J Heart Valve Dis. 2004 Jan;13(1):25-6.
Herein, the case is reported of a persistently elevated INR consequent to an interaction between warfarin and cranberry juice in a patient with a prosthetic mitral valve. The elevation in INR was noted two weeks after the patient began to drink cranberry juice. Subsequent symptoms included postoperative bleeding problems. The bleeding was thought due to a biologically plausible interaction between the drug and the juice. It was concluded that patients taking warfarin should limit their cranberry juice intake.
本文报道了一例人工二尖瓣置换术后患者因华法林与蔓越莓汁相互作用导致国际标准化比值（INR）持续升高的病例。患者开始饮用蔓越莓汁两周后发现INR升高。随后出现术后出血问题。出血被认为是药物与果汁之间存在生物学上合理的相互作用所致。结论是服用华法林的患者应限制蔓越莓汁的摄入量。
