Sir-Petermann T, Maliqueo M, Pérez-Bravo F, Angel B, Carvajal F, del Solar M P, Benítez R
Laboratorio de Endocrinología y Metabolismo, Unidad de Endocrinología, Departamento de Medicina, Facultad de Medicina Occidente, Universidad de Chile.
Rev Med Chil. 2001 Jul;129(7):805-12.
Polycystic ovary syndrome (PCOS) is a very common disorder that occurs up to 10% of premenopausal women. Although PCOS is known to be associated with a higher reproductive morbility and increased risk of hormone dependent-cancer, its diagnosis is particularly important because PCOS is strongly linked to insulin resistance. This involves a major risk of early metabolic and cardiovascular complications. On the other hand, the prevalence of metabolic disorders associated with insulin resistance is higher in family members of patients with PCOS than in those of normal women, which suggests that the treatment of this syndrome should be preventive rather than symptomatic. For that reason, PCOS might be considered a signal of a family disorder, a route to diabetes and a public health problem.
多囊卵巢综合征(PCOS)是一种非常常见的疾病,在绝经前女性中发病率高达10%。尽管已知PCOS与较高的生殖发病率以及激素依赖性癌症风险增加有关,但其诊断尤为重要,因为PCOS与胰岛素抵抗密切相关。这涉及早期代谢和心血管并发症的重大风险。另一方面,PCOS患者家庭成员中与胰岛素抵抗相关的代谢紊乱患病率高于正常女性家庭成员,这表明该综合征的治疗应是预防性的而非对症治疗。因此,PCOS可能被视为一种家族性疾病的信号、通往糖尿病的途径以及一个公共卫生问题。