Benítez R, Sir-Petermann T, Palomino A, Angel B, Maliqueo M, Pérez F, Calvillán M
Laboratorio de Endocrinología y Metabolismo, Unidad de Endocrinología, Departamento de Medicina, Facultad de Medicina Occidente, Universidad de Chile, Las Palmeras 299, Int. Quinta Normal.
Rev Med Chil. 2001 Jul;129(7):707-12.
About 60% of patients with polycystic ovary syndrome (PCOS) have insulin resistance, predisposing them to the premature coronary disease and type 2-diabetes mellitus. However, the history of metabolic disorders in family members of patients with PCOS has been seldom documented in the literature.
To evaluate the family profile of metabolic disorders of PCOS patients and to determine their relative risk of developing one of them in comparison to a control group.
Sixty PCOS patients were evaluated. The control group were 60 normal women. The data were obtained from the clinical history and personal interview with the patients, the controls and their relatives (brothers, parents and grandparents). The metabolic disorders considered were: dyslipidemia, obesity, hypertension and diabetes.
The ages were similar between groups (PCOS: 24.0 +/- 6.3; control group: 24.8 +/- 6.2 years). The prevalence of metabolic disorders was 62% in the relatives of the PCOS patients and 27.8% in the relatives of the control group (p < 0.005). The probability to develop a metabolic disorder within the family was 2.7 (2.2-3.3) fold higher in the PCOS group compared to the control group. The risk of developing hypertension, dyslipidemia, obesity and diabetes was 2.1 (1.5-2.9); 1.8 (1.5-2.7); 3.6 (2.6-4.9) and 2.7 (1.8-3.9), respectively, in the PCOS group compared to the control group.
The probability of finding a metabolic disorder in the families of PCOS patients, is 2.7 fold higher than in the control group families. The metabolic disorders are more frequent in parents and grandparents of the PCOS patients than in those of normal women.
约60%的多囊卵巢综合征（PCOS）患者存在胰岛素抵抗，这使他们易患早发性冠状动脉疾病和2型糖尿病。然而，PCOS患者家庭成员的代谢紊乱病史在文献中鲜有记载。
评估PCOS患者代谢紊乱的家族情况，并确定与对照组相比他们患其中一种代谢紊乱的相对风险。
对60例PCOS患者进行评估。对照组为60名正常女性。数据来自患者、对照组及其亲属（兄弟、父母和祖父母）的临床病史和个人访谈。所考虑的代谢紊乱包括：血脂异常、肥胖、高血压和糖尿病。
两组年龄相似（PCOS组：24.0±6.3岁；对照组：24.8±6.2岁）。PCOS患者亲属中代谢紊乱的患病率为62%，对照组亲属中为27.8%（p<0.005）。PCOS组家庭中发生代谢紊乱的概率比对照组高2.7（2.2 - 3.3）倍。与对照组相比，PCOS组患高血压、血脂异常、肥胖和糖尿病的风险分别为2.1（1.5 - 2.9）；1.8（1.5 - 2.7）；3.6（2.6 - 4.9）和2.7（1.8 - 3.9）。
在PCOS患者家庭中发现代谢紊乱的概率比对照组家庭高2.7倍。PCOS患者的父母和祖父母比正常女性的父母和祖父母更容易出现代谢紊乱。
