促甲状腺激素释放激素在体外刺激大鼠伏隔核切片释放[3H] - 多巴胺。
Thyrotrophin releasing hormone stimulates release of [3H]-dopamine from slices of rat nucleus accumbens in vitro.
作者信息
Kerwin R W, Pycock C J
出版信息
Br J Pharmacol. 1979 Nov;67(3):323-5. doi: 10.1111/j.1476-5381.1979.tb08682.x.
Abstract
Thyrotrophin releasing hormone (TRH) (25 to 100 microM) was found to stimulate the efflux of [3Hu-dopamine from small slices of rat nucleus accumbens, but not from similar slices of rat caudate nucleus. Uptake inhibition was not responsible for this action, since at 10 and 50 microM TRH had no effect on the ability of small slices of nucleus accumbens to accumulate radioactivity when incubated with 10(-7) M [3H]-dopamine. In addition the hormone had no effect on basal or dopamine-stimulated adenylate cyclase, nor did it displace [3H]-spiperone binding, in membrane preparations from nucleus accumbens.
摘要
促甲状腺激素释放激素（TRH）（25至100微摩尔）被发现可刺激大鼠伏隔核薄片中[3H] - 多巴胺的流出，但对大鼠尾状核的类似薄片无此作用。摄取抑制并非此作用的原因，因为在10和50微摩尔时，TRH对伏隔核薄片与10（-7）M [3H] - 多巴胺一起孵育时积累放射性的能力没有影响。此外，该激素对基础或多巴胺刺激的腺苷酸环化酶无影响，在伏隔核的膜制剂中也不取代[3H] - 螺哌隆结合。
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Thyrotropin releasing hormone: enhancement of dopa activity by a hypothalamic hormone.促甲状腺激素释放激素：一种下丘脑激素对多巴活性的增强作用。
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TRH potentiates behavioural changes following increased brain 5-hydroxytryptamine accumulation in rats.促甲状腺激素释放激素增强大鼠脑内5-羟色胺积累后行为的变化。
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The dopamine receptor: differential binding of d-LSD and related agents to agonist and antagonist states.多巴胺受体：d-麦角酸二乙酰胺及相关药物与激动剂和拮抗剂状态的差异结合。
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Central effects of thyrotropin-releasing factor (TRF); interaction with some antipsychotic drugs.促甲状腺素释放因子（TRF）的中枢效应；与某些抗精神病药物的相互作用。
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