Kerwin R W, Pycock C J
Br J Pharmacol. 1979 Nov;67(3):323-5. doi: 10.1111/j.1476-5381.1979.tb08682.x.
Thyrotrophin releasing hormone (TRH) (25 to 100 microM) was found to stimulate the efflux of [3Hu-dopamine from small slices of rat nucleus accumbens, but not from similar slices of rat caudate nucleus. Uptake inhibition was not responsible for this action, since at 10 and 50 microM TRH had no effect on the ability of small slices of nucleus accumbens to accumulate radioactivity when incubated with 10(-7) M [3H]-dopamine. In addition the hormone had no effect on basal or dopamine-stimulated adenylate cyclase, nor did it displace [3H]-spiperone binding, in membrane preparations from nucleus accumbens.
促甲状腺激素释放激素（TRH）（25至100微摩尔）被发现可刺激大鼠伏隔核薄片中[3H] - 多巴胺的流出，但对大鼠尾状核的类似薄片无此作用。摄取抑制并非此作用的原因，因为在10和50微摩尔时，TRH对伏隔核薄片与10（-7）M [3H] - 多巴胺一起孵育时积累放射性的能力没有影响。此外，该激素对基础或多巴胺刺激的腺苷酸环化酶无影响，在伏隔核的膜制剂中也不取代[3H] - 螺哌隆结合。
