Costall B, Hui S C, Metcalf G, Naylor R J
Eur J Pharmacol. 1979 Jan 1;53(2):143-50. doi: 10.1016/0014-2999(79)90159-6.
20 microgram TRH injected bilaterally into the caudate-putamen, tuberculum olfactorium, nucleus accumbens, amygdala, lateral ventricles, midbrain or cerebral cortex failed to induce any increase in locomotor activity (measured using photocells), although other behavioural changes were observed after each injection, and included body shakes, limb tremor, repetitive head and limb movements, biting, scratching and an alert appearance. These behavioural changes could result in positive readings from equipment used to measure locomotor activity, but careful investigations focussing on the nucleus accumbens used photocell boxes, activity wheels and Animex recorders to emphasise the inability of intracerebral TRH (10--40 microgram) to enhance locomotor activity. Intraaccumbens TRH also failed to enhance amphetamine hyperactivity or reduce the motor depression caused by haloperidol and analeptic drugs. The data do not support a central locomotor stimulant action of TRH.
向尾状核-壳核、嗅结节、伏隔核、杏仁核、侧脑室、中脑或大脑皮质双侧注射20微克促甲状腺激素释放激素（TRH），未能引起任何运动活动增加（使用光电管测量），尽管每次注射后观察到了其他行为变化，包括身体抖动、肢体震颤、头部和肢体重复运动、咬、抓以及警觉的样子。这些行为变化可能导致用于测量运动活动的设备出现阳性读数，但针对伏隔核的仔细研究使用了光电管箱、活动轮和Animex记录仪，以强调脑内注射TRH（10 - 40微克）无法增强运动活动。伏隔核内注射TRH也未能增强苯丙胺引起的多动，或减轻氟哌啶醇和兴奋药引起的运动抑制。这些数据不支持TRH具有中枢运动刺激作用。
