在冈比亚，结核病接触者而非患者对早期分泌性抗原靶6（ESAT-6）的γ干扰素反应高于社区对照组。

Tuberculosis contacts but not patients have higher gamma interferon responses to ESAT-6 than do community controls in The Gambia.

作者信息

Vekemans J, Lienhardt C, Sillah J S, Wheeler J G, Lahai G P, Doherty M T, Corrah T, Andersen P, McAdam K P, Marchant A

机构信息

Medical Research Council Laboratories, Fajara, The Gambia.

出版信息

Infect Immun. 2001 Oct;69(10):6554-7. doi: 10.1128/IAI.69.10.6554-6557.2001.

DOI:10.1128/IAI.69.10.6554-6557.2001

PMID:11553606

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC98797/

Abstract

The Mycobacterium tuberculosis antigen ESAT-6 has been proposed for tuberculosis immunodiagnosis. In The Gambia, 30% of community controls produced gamma interferon (IFN-gamma) in response to ESAT-6. Increased proportions of responders and intensities of responses were found in household contacts. Responses that were initially low in tuberculosis patients increased after treatment. An ESAT-6 IFN-gamma assay will be of limited use in the diagnosis of tuberculosis in countries where tuberculosis is endemic. Its role in contact tracing should be evaluated further.

摘要

结核分枝杆菌抗原ESAT-6已被用于结核病的免疫诊断。在冈比亚，30%的社区对照者对ESAT-6产生γ干扰素（IFN-γ）。在家庭接触者中，应答者比例和应答强度均有所增加。结核病患者最初较低的应答在治疗后有所增加。在结核病流行的国家，ESAT-6 IFN-γ检测在结核病诊断中的应用将受到限制。其在接触者追踪中的作用应进一步评估。