Kass L
Am J Clin Pathol. 1975 Jul;64(1):53-7. doi: 10.1093/ajcp/64.1.53.
Cytochemical studies were performed on erythrocytes containing Cabot rings from the peripheral blood of two patients with severe untreated pernicious anemia. These studies demonstrated that the Cabot ring contained arginine-rich histone and non-hemoglobin iron. Structures that may represent precursors of Cabot rings were found in stippled late intermediate marrow megaloblasts. The Cabot ring may result in part from abnormalities in metabolism of both iron and arginine-rich histone that are known to occur in pernicious anemia.
对两名未经治疗的严重恶性贫血患者外周血中含有卡波环的红细胞进行了细胞化学研究。这些研究表明，卡波环含有富含精氨酸的组蛋白和非血红蛋白铁。在有嗜碱性点彩的晚期中间型骨髓巨幼红细胞中发现了可能代表卡波环前体的结构。卡波环可能部分源于恶性贫血中已知会出现的铁和富含精氨酸的组蛋白代谢异常。
