Kass L
Am J Clin Pathol. 1977 Apr;67(4):371-3. doi: 10.1093/ajcp/67.4.371.
Periodic acid-Schiff-positive material representing glycogen was found in bone marrow megaloblasts at all stages of maturation from 11 patients with severe untreated pernicious anemia. This accumulation of glycogen in megaloblasts, which are known to have disordered biosynthesis of DNA, RNA, and histones, suggests that carbohydrate metabolism may also be abnormal in vitamin B12 deficiency, perhaps as a result of an abnormality in the enzyme amylophosphorylase.
在11例未经治疗的严重恶性贫血患者的骨髓巨幼红细胞中，各个成熟阶段均发现有代表糖原的过碘酸-希夫阳性物质。已知巨幼红细胞存在DNA、RNA和组蛋白生物合成紊乱，而其中糖原的这种蓄积提示，维生素B₁₂缺乏时碳水化合物代谢可能也异常，这或许是淀粉磷酸化酶异常所致。
