Morita K, Kawashima Y, Irita K, Kobayayashi T, Goto Y, Iwao Y, Seo N, Tsuzaki K, Dohi S
Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700-8558.
Masui. 2001 Aug;50(8):909-21.
Perioperative mortality and morbidity in Japan from Jan. 1 to Dec. 31, were studied retrospectively. Committee on Operating Room Safety of Japanese Society of Anesthesiologists (JSA) sent confidential questionnaires to 774 Certified Training Hospitals of JSA and received answers from 60.2% of the hospitals. We analyzed their answers with a special reference to the age group. The total number of anesthetics available for this analysis was 732,788. All cases were divided in to 7 groups; group A(< 1 months), group B(< 12 months), group C(< 5 years), group D(< 18 years), group E (< 65 years), group F(< 85 years), and group G(> 85 years). The incidences of all critical events including cardiac arrest, severe hypotension, and severe hypoxemia were 168.14, 47.86, 24.63, 14.65, 28.43, 50.4, and 43.68 per 10,000 in patients with group A, B, C, D, E, F, and G, respectively. The overall mortality rate (death during anesthesia and within 7th postoperative day) were 74.10, 6.63, 3.30, 3.07, 4.82, 13.74, and 11.84 per 10,000 anesthetics in patients with group A, B, C, D, E, F, and G, respectively. The incidences of cardiac arrest were 54.15, 8.84, 5.08, 2.56, 4.84, 11.02, and 6.66 per 10,000 in patients with group A, B, C, D, E, F, and G, respectively. The mortality rates after cardiac arrest were 42.75, 2.95, 2.54, 1.70, 2.00, 6.56, and 5.18 in patients with group A, B, C, D, E, F, and G, respectively. The incidences of all critical events, the incidence of cardiac arrest, and the overall mortality rate were much higher in group A than other groups and lower in group D. Mortality and morbidity due to all kinds of causes including anesthetic management, intraoperative events, co-existing diseases, and operation were as follows. The incidence of all critical events attributable to co-existing disease were the highest in these four groups, and 94.04, 15.46, 7.87, 6.13, 7.26, 17.38, and 16.29 per 10,000 in patients with group A, B, C, D, E, F, and G, respectively. The incidences of all critical events attributable to anesthetic management were 31.35, 16.94, 4.60, 6.09, 10.77, and 14.07 per 10,000 in patients with group A, B, C, D, E, F, and G, respectively. The incidence of cardiac arrest in group A was much more attributable to co-existing disease and operation than other causes. The incidences of cardiac arrest attributable to anesthetic management were 0.00, 1.47, 0.25, 0.34, 0.83, 0.92, and 0.22 per 10,000 in patients with group A, B, C, D, E, F, and G, respectively. The mortality rates in these groups were 0.00, 0.00, 0.00, 0.17, 0.07, 0.05, and 1.48, and no death was found in cases under 5 years of age. The two cases of death in G group were due to too high anesthesia levels in spinal anesthesia. Other causes including overdose of anesthetics, toxic effect of local anesthetic, improper management of airway, and incompatible blood transfusion were preventable with the anesthesiologists' effort in protocol development and skilled assistance.
对1月1日至12月31日期间日本围手术期的死亡率和发病率进行了回顾性研究。日本麻醉医师协会手术室安全委员会向774家日本麻醉医师协会认证培训医院发送了保密问卷,收到了60.2%的医院的回复。我们特别参照年龄组对回复进行了分析。可用于此次分析的麻醉总数为732,788例。所有病例分为7组:A组(<1个月)、B组(<12个月)、C组(<5岁)、D组(<18岁)、E组(<65岁)、F组(<85岁)和G组(>85岁)。A、B、C、D、E、F和G组患者中,包括心脏骤停、严重低血压和严重低氧血症在内的所有严重事件的发生率分别为每10,000例168.14、47.86、24.63、14.65、28.43、50.4和43.68例。总体死亡率(麻醉期间及术后第7天内死亡)在A、B、C、D、E、F和G组患者中分别为每10,000例麻醉74.10、6.63、3.30、3.07、4.82、13.74和11.84例。A、B、C、D、E、F和G组患者中心脏骤停的发生率分别为每10,000例54.15、8.84、5.08、2.56、4.84、11.02和6.66例。心脏骤停后的死亡率在A、B、C、D、E、F和G组患者中分别为42.75、2.95、2.54、1.70、2.00、6.56和5.18。A组中所有严重事件的发生率、心脏骤停的发生率和总体死亡率均远高于其他组,而D组则较低。包括麻醉管理、术中事件、并存疾病和手术在内的各种原因导致的死亡率和发病率如下。并存疾病导致的所有严重事件的发生率在这四组中最高,A、B、C、D组患者中分别为每10,000例94.04、15.46、7.87和6.13例,E、F和G组分别为每10,000例7.26、17.38和16.29例。麻醉管理导致的所有严重事件的发生率在A、B、C、D、E、F和G组患者中分别为每10,000例31.35、16.94、4.60、6.09、10.77和14.07例。A组中心脏骤停更多归因于并存疾病和手术而非其他原因。麻醉管理导致的心脏骤停的发生率在A、B、C、D、E、F和G组患者中分别为每10,000例0.00、1.47、0.25、0.34、0.83、0.92和0.22例。这些组中的死亡率分别为0.00、0.00、0.00、0.17、0.07、0.05和1.48,5岁以下患者未发现死亡病例。G组的两例死亡是由于脊髓麻醉时麻醉水平过高。包括麻醉剂过量、局部麻醉剂的毒性作用、气道管理不当和输血不相容等其他原因,通过麻醉医师在制定方案和提供熟练协助方面的努力是可以预防的。