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[日本麻醉医师协会认证培训医院2000年围手术期死亡率和发病率年度报告:特别提及麻醉方法——日本麻醉医师协会手术室安全委员会报告]

[Annual report of perioperative mortality and morbidity for the year 2000 at certified training hospitals of Japanese Society of Anesthesiologists: with a special reference to anesthetic methods--report of the Japanese Society of Anesthesiologists Committee on Operating Room Safety].

作者信息

Seo Norimasa, Kawashima Yasuo, Irita Kazuo, Shiraish Yoshito, Tanaka Yoshifumi, Nakata Yasuo, Morita Kiyoshi, Iwao Yasuhide, Tsuzaki Koichi, Kobayashi Tsutomu, Goto Yasuyuki, Dohi Shuji

机构信息

Department of Anesthesiology and Critical Care Medicine, Jichi Medical School, Tochigi 329-0498.

出版信息

Masui. 2002 May;51(5):542-56.

Abstract

The Committee on Operating Room Safety of Japan Society of Anesthesiologists (JSA) sends annually confidential questionnaires of perioperative mortality and morbidity (cardiac arrest, severe hypotension, severe hypoxia) to Certified Training Hospitals of JSA. This report is a special reference to anesthetic methods in perioperative mortality and morbidity in 2000. Five hundreds and twenty hospitals reported perioperative mortality and morbidity referred to anesthetic methods and total numbers of reported cases were 910,007. The percentage of cases reported by each anesthetic method was as follows; inhalation anesthesia 45.47%, total intravenous anesthesia (TIVA) 6.15%, inhalation anesthesia + epidural or spinal or conduction block 24.48%, TIVA + epidural or spinal or conduction block 6.33%, spinal with continuous epidural block (CSEA) 3.67%, epidural anesthesia 1.92%, spinal anesthesia 10%, conduction block 0.47% and others 1.49%. The incidence of cardiac arrest per 10,000 cases due to all etiology (anesthetic management, preoperative complications, intraoperative complications, surgery, others) is estimated to be 6.55 cases in average; 5.36 cases in inhalation anesthesia, 30.72 cases in total intravenous anesthesia (TIVA), 4.62 cases in inhalation anesthesia + epidural or spinal or conduction block, 2.6 cases in TIVA + epidural or spinal or conduction block, 1.2 cases in spinal with continuous epidural block (CSEA), 0.57 cases in epidural anesthesia, 1.65 cases in spinal anesthesia, 2.36 cases in conduction block and 46.38 cases in other methods. However, the incidence of cardiac arrest per 10,000 cases totally attributable to anesthetic management is estimated to be 0.54 cases in average; 0.34 cases in inhalation anesthesia, 1.07 cases in TIVA, 0.58 cases in inhalation anesthesia + epidural or spinal or conduction block, 0.17 cases in TIVA + epidural or spinal or conduction block, 0.9 cases in CSEA, 0.57 cases in epidural anesthesia, 0.99 cases in spinal anesthesia, zero case in conduction block and 1.47 cases in other methods. The incidence of severe hypotension per 10,000 cases due to all etiology is estimated to be 11.14 cases in average; 11.31 cases in inhalation anesthesia, 36.61 cases in TIVA, 9.29 cases in inhalation anesthesia + epidural or spinal or conduction block, 6.59 cases in TIVA + epidural or spinal or conduction block, 3.59 cases in CSEA, 6.3 cases in epidural anesthesia, 4.39 cases in spinal anesthesia, 2.36 cases in conduction block and 23.56 cases in other methods. On the other hand, the incidence of severe hypotension per 10,000 cases totally attributable to anesthetic management is estimated to be 1.25 cases in average; 0.97 cases in inhalation anesthesia, 0.89 cases in TIVA, 1.39 cases in inhalation anesthesia + epidural or spinal or conduction block, 1.39 cases in TIVA + epidural or spinal or conduction block, 2.09 cases in CSEA, 3.44 cases in epidural anesthesia, 1.87 cases in spinal anesthesia, zero case in conduction block and zero case in other methods. The incidence of severe hypoxia per 10,000 cases due to all etiology is estimated to be 4.8 cases in average; 6.35 cases in inhalation anesthesia, 9.64 cases in TIVA, 3.82 cases in inhalation anesthesia + epidural or spinal or conduction block, 2.26 cases in TIVA + epidural or spinal or conduction block, 0.3 cases in CSEA, 1.15 case in epidural anesthesia, 1.21 cases in spinal anesthesia, zero case in conduction block and 5.89 cases in other methods. On the other hands, the incidence of severe hypoxia per 10,000 cases totally attributable to anesthetic management is estimated to be 1.98 cases in average; 3.09 cases in inhalation anesthesia, 2.32 cases in TIVA, 1.3 cases in inhalation anesthesia + epidural or spinal or conduction block, 0.87 cases in TIVA + epidural or spinal or conduction block, zero case in CSEA, zero case in epidural anesthesia, 0.55 cases in spinal anesthesia, zero case in conduction block and zero case in other methods. The mortality rate of cardiac arrest within 7 postoperative days per 10,000 cases due to all etiology is estimated to be 3.55 (54.2%) cases in average; 3.12 (58.1%) cases in inhalation anesthesia, 19.29 (62.8%) cases in TIVA, 1.17 (25.2%) cases in inhalation anesthesia + epidural or spinal or conduction block, 0.52 (20%) cases in TIVA + epidural or spinal or conduction block, zero cases in CSEA, zero case in epidural anesthesia, 0.33 (20%) cases in spinal anesthesia, zero case in conduction block and 39.76 (85.7%) cases in other methods. On the other hands, the mortality rate of cardiac arrest per 10,000 cases totally attributable to anesthesia is estimated to be 0.07 (12.2%) case in average, 0.07 (21.4%) case in inhalation anesthesia, 0.18 (16.8%) case in TIVA, zero case in inhalation anesthesia + epidural or spinal or conduction block, zero case in TIVA + epidural or spinal or conduction block, zero case in CSEA, zero case in epidural anesthesia, 0.11 (11.1%) case in spinal anesthesia, zero case in conduction block and 0.74 (50%) case in other methods. Five major combinations of listed critical incidents, causes and anesthetic methods were as follows: 18.93 cases in TIVA, preoperative complications and severe hypotension; 18.75 cases in TIVA, preoperative complications and cardiac arrest; 11.07 cases in TIVA, surgery and severe hypotension; 6.79 cases in TIVA, surgery and cardiac arrest; 5.24 cases in inhalation anesthesia, preoperative complications and severe hypotension. In summary: 1. There was no significant difference with regard to perioperative mortality and morbidity due to anesthetic management among anesthetic methods. 2. The percentage of each anesthetic method in 2000 was not different significantly from that in 1999 in spite of increased cases reported. 3. Incidence of severe hypotension due to all etiology of TIVA in 2000 decreased significantly compared with that in 1999 (P < 0.05). This may be attributed to the decreased incidence in preoperative complication (shock) and massive bleeding due to surgery.

摘要

日本麻醉医师协会(JSA)手术室安全委员会每年向JSA认证培训医院发送围手术期死亡率和发病率(心脏骤停、严重低血压、严重缺氧)的保密调查问卷。本报告特别参考了2000年围手术期死亡率和发病率中的麻醉方法。520家医院报告了围手术期死亡率和发病率,并提及了麻醉方法,报告的病例总数为910,007例。每种麻醉方法报告的病例百分比分别如下:吸入麻醉45.47%,全静脉麻醉(TIVA)6.15%,吸入麻醉+硬膜外或脊髓或传导阻滞24.48%,TIVA+硬膜外或脊髓或传导阻滞6.33%,腰麻联合连续硬膜外阻滞(CSEA)3.67%,硬膜外麻醉1.92%,腰麻10%,传导阻滞0.47%,其他1.49%。因所有病因(麻醉管理、术前并发症、术中并发症、手术、其他)导致的每10,000例病例中心脏骤停的发生率估计平均为6.55例;吸入麻醉中为5.36例,全静脉麻醉(TIVA)中为30.72例,吸入麻醉+硬膜外或脊髓或传导阻滞中为4.62例,TIVA+硬膜外或脊髓或传导阻滞中为2.6例,腰麻联合连续硬膜外阻滞(CSEA)中为1.2例,硬膜外麻醉中为0.57例,腰麻中为1.65例,传导阻滞中为2.36例,其他方法中为46.38例。然而,完全归因于麻醉管理的每10,000例病例中心脏骤停的发生率估计平均为0.54例;吸入麻醉中为0.34例,TIVA中为1.07例,吸入麻醉+硬膜外或脊髓或传导阻滞中为0.58例,TIVA+硬膜外或脊髓或传导阻滞中为0.17例,CSEA中为0.9例,硬膜外麻醉中为0.57例,腰麻中为0.99例,传导阻滞中为零例,其他方法中为1.47例。因所有病因导致的每10,000例病例中严重低血压的发生率估计平均为11.14例;吸入麻醉中为11.31例,TIVA中为36.61例,吸入麻醉+硬膜外或脊髓或传导阻滞中为9.29例,TIVA+硬膜外或脊髓或传导阻滞中为6.59例,CSEA中为3.59例,硬膜外麻醉中为6.3例,腰麻中为4.39例,传导阻滞中为2.36例,其他方法中为23.56例。另一方面,完全归因于麻醉管理的每10,000例病例中严重低血压的发生率估计平均为1.25例;吸入麻醉中为0.97例,TIVA中为0.89例,吸入麻醉+硬膜外或脊髓或传导阻滞中为1.39例،TIVA+硬膜外或脊髓或传导阻滞中为1.39例,CSEA中为2.09例,硬膜外麻醉中为3.44例,腰麻中为1.87例,传导阻滞中为零例,其他方法中为零例。因所有病因导致的每10,000例病例中严重缺氧的发生率估计平均为4.8例;吸入麻醉中为6.35例,TIVA中为9.64例,吸入麻醉+硬膜外或脊髓或传导阻滞中为3.82例,TIVA+硬膜外或脊髓或传导阻滞中为2.26例,CSEA中为0.3例,硬膜外麻醉中为1.15例,腰麻中为1.21例,传导阻滞中为零例,其他方法中为5.89例。另一方面,完全归因于麻醉管理的每10,000例病例中严重缺氧的发生率估计平均为1.98例;吸入麻醉中为3.09例,TIVA中为2.32例,吸入麻醉+硬膜外或脊髓或传导阻滞中为1.3例,TIVA+硬膜外或脊髓或传导阻滞中为0.87例,CSEA中为零例,硬膜外麻醉中为零例,腰麻中为0.55例,传导阻滞中为零例,其他方法中为零例。因所有病因导致的术后7天内心脏骤停的死亡率估计平均为每10,000例病例3.55(54.2%)例;吸入麻醉中为3.12(58.1%)例,TIVA中为19.29(62.8%)例,吸入麻醉+硬膜外或脊髓或传导阻滞中为1.17(25.2%)例,TIVA+硬膜外或脊髓或传导阻滞中为0.52(20%)例,CSEA中为零例,硬膜外麻醉中为零例,腰麻中为0.33(20%)例,传导阻滞中为零例,其他方法中为39.76(85.7%)例。另一方面,完全归因于麻醉的每10,000例病例中心脏骤停的死亡率估计平均为0.07(12.2%)例,吸入麻醉中为0.07(21.4%)例,TIVA中为0.18(16.8%)例,吸入麻醉+硬膜外或脊髓或传导阻滞中为零例,TIVA+硬膜外或脊髓或传导阻滞中为零例,CSEA中为零例,硬膜外麻醉中为零例,腰麻中为0.11(11.1%)例,传导阻滞中为零例,其他方法中为0.74(50%)例。列出的严重事件、原因和麻醉方法的五种主要组合如下:TIVA、术前并发症和严重低血压18.93例;TIVA、术前并发症和心脏骤停18.75例;TIVA、手术和严重低血压11.07例;TIVA、手术和心脏骤停6.79例;吸入麻醉、术前并发症和严重低血压5.24例。总结如下:1. 麻醉方法之间因麻醉管理导致的围手术期死亡率和发病率没有显著差异。2. 尽管报告的病例有所增加,但2000年每种麻醉方法的百分比与1999年相比没有显著差异。3. 2000年TIVA因所有病因导致的严重低血压发生率与1999年相比显著降低(P<0.05)。这可能归因于术前并发症(休克)和手术导致的大量出血发生率降低。

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