Wiesenfeld S L, Gajdusek D C
Am J Hum Genet. 1975 Jul;27(4):498-504.
The validity of the reported association between GcAb and kuru is analyzed. Phenotypes with one or more GcAb genes have an increased incidence of the disease at the expense of Gc 1-1 and Gc 2-2. Incidence ratios of kuru associated with various phenotypes examined over the linguistic groups studied indicate that only Gc Ab-Ab persons have a significantly greater chance of dying of kuru. The association X2 for the incidence ratio for those phenotypes possessing only one GcAb gene is significant, but there is significant heterogeneity between groups studied. Those of the Gc Ab-Ab phenotype are six times as likely to contract kuru as the baseline group. Criticisms of this analysis include difficulties defining an adequate control group in such heterogeneous populations, errors in determination of Gc phenotypes, inclusion of persons incubating kuru in the control groups, and questions of validity of statistical tests in isolated inbred populations.
分析了所报道的GcAb与库鲁病之间关联的有效性。具有一个或多个GcAb基因的表型会使该疾病的发病率增加，代价是Gc 1-1和Gc 2-2。在所研究的语言群体中，与各种表型相关的库鲁病发病率比率表明，只有Gc Ab-Ab个体死于库鲁病的几率显著更高。仅拥有一个GcAb基因的那些表型的发病率比率的关联X2具有显著性，但所研究的群体之间存在显著的异质性。Gc Ab-Ab表型的个体感染库鲁病的可能性是基线组的六倍。对该分析的批评包括在如此异质的人群中难以定义一个适当的对照组、Gc表型测定中的误差、在对照组中纳入了正在潜伏库鲁病的个体以及在孤立的近亲繁殖群体中统计检验有效性的问题。
