库鲁病：从巴布亚新几内亚回到过去，追寻尼安德特人的灭绝之旅。

Kuru: a journey back in time from papua new Guinea to the neanderthals' extinction.

机构信息

Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Kosciuszki st. 4, Lodz 90-419, Poland.

出版信息

Pathogens. 2013 Jul 18;2(3):472-505. doi: 10.3390/pathogens2030472.

DOI:10.3390/pathogens2030472

PMID:25437203

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4235695/

Abstract

Kuru, the first human transmissible spongiform encephalopathy was transmitted to chimpanzees by D. Carleton Gajdusek (1923-2008). In this review, I briefly summarize the history of this seminal discovery along its epidemiology, clinical picture, neuropathology and molecular genetics. The discovery of kuru opened new windows into the realms of human medicine and was instrumental in the later transmission of Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease as well as the relevance that bovine spongiform encephalopathy had for transmission to humans. The transmission of kuru was one of the greatest contributions to biomedical sciences of the 20th century.

摘要

库鲁病，首例人类传染性海绵状脑病，由 D. 卡勒顿·盖杜谢克（1923-2008 年）传播给黑猩猩。在这篇综述中，我简要概述了这一开创性发现的历史，包括其流行病学、临床特征、神经病理学和分子遗传学。库鲁病的发现为人类医学领域开辟了新的视野，并对后来克雅氏病、格斯特曼-施特劳斯勒-谢因克病的传播以及牛海绵状脑病对人类传播的相关性产生了影响。库鲁病的传播是 20 世纪对生物医学科学的最大贡献之一。