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挪威奥斯陆的多发性硬化症:1995年1月1日的患病率及25年期间的发病率

Multiple sclerosis in Oslo, Norway: prevalence on 1 January 1995 and incidence over a 25-year period.

作者信息

Celius E G, Vandvik B

机构信息

Department of Neurology, Ullevål Sykehus, Oslo City Hospitals, N-0407 Oslo, Norway.

出版信息

Eur J Neurol. 2001 Sep;8(5):463-9. doi: 10.1046/j.1468-1331.2001.00269.x.

Abstract

The Oslo Multiple Sclerosis (MS) Registry was established in 1990, and this is the first report on the prevalence and incidence of MS in the city of Oslo, Norway. The prevalence rate of definite MS on 1 January 1995 was 120.4/10(5). Inclusion of patients of native Norwegian ancestry only and exclusion of non-Norwegian immigrants yielded a prevalence rate of 136.0/10(5). A similar prevalence rate (136.5/10(5)) was found when patients and immigrants from the other Nordic countries (Finland, Sweden, Denmark) were included. Segregation of the native Norwegian patients according to the counties where they were born showed no significant differences except for a disproportionate increase of patients born in the inland county of Oppland. A total of 794 cases were resident in Oslo at the time of a diagnosis of definite MS in the period 1972-99. The crude average annual incidence rate for each 5-year period, between 1972 and 1996, increased significantly from 3.7/10(5) in the 1972-76 to 8.7/10(5) in the 1992-96 period. The increase was more marked in relapsing-remitting (RR) than in primary progressive disease and in female cases.

摘要

奥斯陆多发性硬化症(MS)登记处成立于1990年,这是关于挪威奥斯陆市MS患病率和发病率的首份报告。1995年1月1日确诊MS的患病率为120.4/10⁵。仅纳入挪威本土血统患者并排除非挪威移民后,患病率为136.0/10⁵。纳入来自其他北欧国家(芬兰、瑞典、丹麦)的患者及移民后,发现了类似的患病率(136.5/10⁵)。根据出生县对挪威本土患者进行分类,除内陆县奥普兰出生的患者不成比例增加外,未发现显著差异。在1972 - 1999年确诊为明确MS的时期,共有794例患者居住在奥斯陆。1972年至1996年期间,每5年的粗平均年发病率从1972 - 1976年的3.7/10⁵显著增加到1992 - 1996年的8.7/10⁵。复发缓解型(RR)疾病的增加比原发性进展型疾病更明显,且女性病例增加更显著。

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