Department of Rehabilitation, Sykehuset Innlandet HF, Gjøvik, Norway.
Acta Neurol Scand. 2011 Oct;124(4):250-7. doi: 10.1111/j.1600-0404.2010.01465.x. Epub 2010 Dec 10.
OBJECTIVES - We report the prevalence and incidence rates of multiple sclerosis (MS) in Oppland County, Norway. METHODS - Records from all patients diagnosed with MS at the two Oppland County hospitals, Gjøvik and Lillehammer during 1989-2001 were evaluated. In addition, all general practitioners in Oppland County reported their patients into the study. RESULTS - The age-adjusted prevalence rate of definite MS was 174.4/ 100 000 on the prevalence day 1 January 2002. When the probable cases were included, the prevalence rate rose to 185.6/100 000. The highest prevalence rates were detected in the northern mountain areas, thus corroborating the results from previous local surveys 30-50 years ago. The prevalence of MS was statistically significantly associated with climatic, socioeconomic and geographic variables in the county. The age-adjusted incidence of definite and probable MS in Oppland County was 6.6/100 000 during 1989-1993 increasing to 7.6/100 000 during 1994-1998. DISCUSSION - We found the highest prevalence rates of MS ever reported in Norway. Our findings indicate a possible influence of environmental factors.
目的 - 我们报告了挪威奥普兰郡多发性硬化症（MS）的患病率和发病率。
方法 - 评估了在 1989-2001 年期间，奥普兰郡两家医院（格约维克和利勒哈默尔）确诊为 MS 的所有患者的记录。此外，奥普兰郡的所有全科医生都将他们的患者报告到该研究中。
结果 - 2002 年 1 月 1 日发病日的年龄调整后明确 MS 的患病率为 174.4/100000。当包括可能病例时，患病率上升至 185.6/100000。在北部山区发现了最高的患病率，这与 30-50 年前的当地调查结果一致。MS 的患病率与该县的气候、社会经济和地理变量具有统计学显著相关性。在 1989-1993 年期间，奥普兰郡明确和可能的 MS 的年龄调整发病率为 6.6/100000，在 1994-1998 年期间增加到 7.6/100000。
讨论 - 我们发现了挪威有史以来报告的最高 MS 患病率。我们的发现表明环境因素可能有影响。
