四名澳大利亚儿童感染阿尔堡短螺旋体
Brachyspira aalborgi infection in four Australian children.
作者信息
Heine R G, Ward P B, Mikosza A S, Bennett-Wood V, Robins-Browne R M, Hampson D J
机构信息
Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Melbourne, Victoria, Australia.
出版信息
J Gastroenterol Hepatol. 2001 Aug;16(8):872-5. doi: 10.1046/j.1440-1746.2001.t01-1-02543.x.
AIM
The clinical presentation of four children and adolescents (two males and two females with a mean age of 12.4 years; range 9-16 years) with colorectal spirochetosis is discussed.
RESULTS
Symptoms included persistent diarrhea (n = 2), rectal bleeding (n = 1) and abdominal pain (n = 2). In all patients, colorectal spirochetosis was an unanticipated finding on colonic histology, and the presence of spirochetes was confirmed by the use of electron microscopy. Spirochetes were identified as Brachyspira aalborgi by using PCR amplification of the bacterial 16S rRNA and nicotinamide adenine dinucleotide oxidase sequences in all four patients. No other enteric pathogens were found.
CONCLUSIONS
Although all patients appeared to respond to antibiotic treatment, the clinical significance of B. aalborgi as a human pathogen requires further investigation.
目的
讨论4例儿童和青少年（2名男性和2名女性，平均年龄12.4岁；范围9 - 16岁）结肠螺旋体病的临床表现。
结果
症状包括持续性腹泻（n = 2）、直肠出血（n = 1）和腹痛（n = 2）。在所有患者中，结肠螺旋体病是结肠组织学检查中意外发现的，通过电子显微镜证实了螺旋体的存在。通过对所有4例患者的细菌16S rRNA和烟酰胺腺嘌呤二核苷酸氧化酶序列进行PCR扩增，将螺旋体鉴定为奥尔堡短螺旋体。未发现其他肠道病原体。
结论
尽管所有患者似乎对抗生素治疗有反应，但奥尔堡短螺旋体作为人类病原体的临床意义需要进一步研究。
Zotero 插件