类胡萝卜素会被自由基降解，但在不同氧张力下对单层脂质体中的脂质过氧化没有影响。

Carotenoids are degraded by free radicals but do not affect lipid peroxidation in unilamellar liposomes under different oxygen tensions.

作者信息

Chen G, Djuric Z

机构信息

Barbara Ann Karmanos Cancer Institute, 110 East Warren Ave., Detroit, MI 48201, USA.

出版信息

FEBS Lett. 2001 Sep 7;505(1):151-4. doi: 10.1016/s0014-5793(01)02671-0.

DOI:10.1016/s0014-5793(01)02671-0

PMID:11557059

Abstract

It has been questioned whether carotenoids can act as antioxidants in biological membranes. Biological membranes can be modeled for studies of lipid peroxidation using unilamellar liposomes. Both carotenoid depletion and lipid peroxidation were increased with increasing oxygen tension in unilamellar liposomes. Carotenoids in such liposomes were found to be very sensitive to degradation by free radicals generated from iron and 2,2'-azobis(2-amidinopropane) dihydrochloride, but they were not protective against lipid peroxidation. Lycopene and beta-carotene were more sensitive to free radical attack than lutein, zeaxanthin, and beta-cryptoxanthin.

摘要

类胡萝卜素是否能在生物膜中充当抗氧化剂一直存在疑问。可以使用单层脂质体模拟生物膜来研究脂质过氧化。在单层脂质体中，随着氧张力的增加，类胡萝卜素的消耗和脂质过氧化都增加了。发现此类脂质体中的类胡萝卜素对铁和2,2'-偶氮二异丁脒二盐酸盐产生的自由基降解非常敏感，但它们对脂质过氧化没有保护作用。与叶黄素、玉米黄质和β-隐黄质相比，番茄红素和β-胡萝卜素对自由基攻击更敏感。