Giordano M O, Ferreyra L J, Isa M B, Martinez L C, Yudowsky S I, Nates S V
Instituto de Virología Dr. José M. Vanella, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Rev Inst Med Trop Sao Paulo. 2001 Jul-Aug;43(4):193-7. doi: 10.1590/s0036-46652001000400003.
Information concerning the disease burden of viral gastroenteritis has important implications for the use and monitoring the impact of public health policies. The present study, carried out in Córdoba city, Argentina, documents the epidemiology of severe viral diarrhea as well as the burden of viral gastrointestinal disease in the hospital children admission. A total of 133 stools were collected from hospitalized children (Town Childhood Hospital) suffering from acute diarrhea and studied for the presence of Group A rotavirus, astrovirus and adenovirus 40/41 by enzyme-immuno assay, between November 1997 and October 1998. Enteric viruses accounted for 42.1% of the total diarrheal cases analyzed. Group A rotaviruses, astroviruses, adenoviruses 40/41 and mixed infections were found in 35.3, 4.5, 1.5, and 0.8% studied specimens respectively. We estimated that 1 in 27 children in the 0-35 month-old cohort/range would be annually hospitalized for a viral gastroenteritis illness. The major impact on viral diarrhea lies on rotaviral infection, accounting for 84.0% of the viral diarrheal cases analyzed and for approximately one third of severe diarrheas requiring hospital admission in Córdoba City, Argentina.
有关病毒性肠胃炎疾病负担的信息对于公共卫生政策的应用及影响监测具有重要意义。本研究在阿根廷科尔多瓦市开展，记录了严重病毒性腹泻的流行病学情况以及医院收治儿童中病毒性胃肠疾病的负担。1997年11月至1998年10月期间，从患有急性腹泻的住院儿童（镇儿童医院）中总共采集了133份粪便样本，通过酶免疫测定法研究其中A组轮状病毒、星状病毒和腺病毒40/41的存在情况。肠道病毒占所分析腹泻病例总数的42.1%。在所研究的样本中，分别发现A组轮状病毒、星状病毒、腺病毒40/41和混合感染的比例为35.3%、4.5%、1.5%和0.8%。我们估计，在0至35个月龄的儿童队列/范围内，每27名儿童中就有1名儿童每年会因病毒性肠胃炎疾病住院。病毒性腹泻的主要影响在于轮状病毒感染，在所分析的病毒性腹泻病例中占84.0%，在阿根廷科尔多瓦市，约占需要住院治疗的严重腹泻病例的三分之一。
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