Wang W, Dow K E, Fraser D D
Department of Paediatrics, Kingston General Hospital, Ontario, Canada.
Ann Neurol. 2001 Sep;50(3):404-9. doi: 10.1002/ana.1138.
The corticotropin releasing hormone (CRH) system has been suggested to initiate seizure activity in the developing brain. However, human data to support this theory is lacking. In this study, we have demonstrated that the expression of CRH, CRH-binding protein, and CRH-R1 (a CRH membrane receptor) were significantly elevated in cortical tissue obtained from 6 children with generalized epilepsy (mean age 8.2+/-1.5 years) relative to age-matched controls (mean age 7.8+/-1.4 years). In contrast, no significant difference in the expression of CRH-R2 was observed. The advent of CRH-R1 receptor antagonists may prove useful as novel anticonvulsants.
促肾上腺皮质激素释放激素（CRH）系统被认为可引发发育中大脑的癫痫活动。然而，缺乏支持该理论的人类数据。在本研究中，我们已证明，相对于年龄匹配的对照组（平均年龄7.8±1.4岁），从6名全身性癫痫患儿（平均年龄8.2±1.5岁）获取的皮质组织中，CRH、CRH结合蛋白和CRH-R1（一种CRH膜受体）的表达显著升高。相比之下，未观察到CRH-R2表达有显著差异。CRH-R1受体拮抗剂的出现可能被证明可作为新型抗惊厥药发挥作用。
