Rutherford M L, Stinger T
Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
Curr Opin Drug Discov Devel. 2001 May;4(3):343-6.
The impact of robotics and automation on the pharmaceutical industry over the last two decades has been significant. In the last ten years, the emphasis of laboratory automation has shifted from the support of manufactured products and quality control of laboratory applications, to research and development. This shift has been the direct result of an increased emphasis on the identification, development and eventual marketing of innovative new products. In this article, we will briefly identify and discuss some of the current trends in laboratory automation in the pharmaceutical industry as they apply to research and development, including screening, sample management, combinatorial chemistry, ADME/Tox and pharmacokinetics.
在过去二十年中,机器人技术和自动化对制药行业产生了重大影响。在过去十年里,实验室自动化的重点已从支持制成品和实验室应用的质量控制,转向了研发。这种转变是由于对创新新产品的识别、开发及最终推向市场的重视程度提高所直接导致的。在本文中,我们将简要识别并讨论制药行业实验室自动化在应用于研发时的一些当前趋势,包括筛选、样品管理、组合化学、药物代谢动力学/毒理学及药代动力学。