Intrepid Labs Inc., MaRS Centre, West Tower, 661 University Avenue Suite 1300, Toronto, ON, M5G 0B7, Canada.
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, M5S 3E5, Canada.
Adv Healthc Mater. 2024 Nov;13(29):e2401312. doi: 10.1002/adhm.202401312. Epub 2024 Aug 18.
Over the last four decades, pharmaceutical companies' expenditures on research and development have increased 51-fold. During this same time, clinical success rates for new drugs have remained unchanged at about 10 percent, predominantly due to lack of efficacy and/or safety concerns. This persistent problem underscores the need to innovate across the entire drug development process, particularly in drug formulation, which is often deprioritized and under-resourced.
在过去的四十年中，制药公司在研发上的支出增长了 51 倍。在此期间，新药的临床成功率一直保持在约 10%左右，主要是由于缺乏疗效和/或安全性问题。这个持续存在的问题突出表明需要在整个药物开发过程中进行创新，特别是在药物制剂方面，这通常被优先考虑和资源不足。
