Moore R H, White R P
Arch Int Pharmacodyn Ther. 1975 Jan;213(1):113-20.
Neuropharmacological effects of doxepin were studied in rabbits to reveal fundamental actions which might explain its clinical efficacy. The results indicate that central effects of this compound are similar to those reported for atropine and the tricyclic antidepressants. In this regard, doxepin produced mydriasis and EEG synchrony without producing overt signs of sleep. It inhibited in a dose-related manner the EEG activation produced by physostigmine. It inhibited the EEG, but not behavioral, effects of methamphetamine. Doxepin enhanced some of the behavioral effects of methamphetamine, as does atropine.
研究了多塞平对家兔的神经药理学作用，以揭示可能解释其临床疗效的基本作用。结果表明，该化合物的中枢作用与阿托品和三环类抗抑郁药报道的作用相似。在这方面，多塞平可引起瞳孔散大和脑电图同步，但不产生明显的睡眠迹象。它以剂量相关的方式抑制毒扁豆碱引起的脑电图激活。它抑制甲基苯丙胺对脑电图的作用，但不抑制其行为作用。与阿托品一样，多塞平增强了甲基苯丙胺的一些行为作用。
