Pickworth W B, White R P
Arch Int Pharmacodyn Ther. 1977 Jan;225(1):64-76.
EEG tracings from conscious restrained rabbits were analyzed by inspection and amplitude integration (electrogenesis). Intravenously, tryptamine in doses of 0.1 and 0.5 mg/kg increased electrogenesis, whereas 1 mg/kg initially decreased and subsequently increased electrogenesis. Higher doses (3, 6 and 12 mg/kg) always caused an immediate and dose-dependent decrease in electrogenesis. Neither atropine nor reserpine pretreatment prevented this decrease, whereas chlorpromazine and methysergide abolished it. Intravenous infusions of tryptamine at 1 mg/kg/min caused a nonsignificant increase in electrogenesis but 2 and 4 mg/kg/min infusions caused a sustained decrease. These results show that tryptamine has a biphasic effect on the cortical EEG: low doses enhance synchrony while high doses alert the EEG. Moreover, analysis of the behavioral, EEG and peripheral effects of tryptamine indicate that different sites of action account for the multiple responses observed. Chlorpromazine and methysergide selectively inhibit the exictatory responses.
通过检查和振幅积分（电发生）对清醒受限家兔的脑电图进行分析。静脉注射剂量为0.1和0.5mg/kg的色胺会增加电发生，而1mg/kg最初会降低电发生，随后又会增加电发生。更高剂量（3、6和12mg/kg）总是会导致电发生立即且呈剂量依赖性降低。阿托品或利血平预处理均不能阻止这种降低，而氯丙嗪和甲基麦角新碱可消除这种降低。以1mg/kg/min的速度静脉输注色胺会导致电发生无明显增加，但以2和4mg/kg/min的速度输注会导致持续降低。这些结果表明，色胺对皮层脑电图有双相作用：低剂量增强同步性，而高剂量使脑电图警觉。此外，对色胺的行为、脑电图和外周效应的分析表明，不同的作用部位导致了观察到的多种反应。氯丙嗪和甲基麦角新碱选择性抑制兴奋反应。
