Kitthaweesin K, Yospaiboon Y
Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Thailand.
J Med Assoc Thai. 2001 May;84(5):628-34.
A randomized, double blind study was carried out to compare the efficacy of dexamethasone and methylprednisolone in the treatment of indirect traumatic optic neuropathy. Twenty-one patients, 20 male and 1 female, were diagnosed as having suffered from indirect traumatic optic neuropathy. The time from injury to treatment was within 7 days. The average age was 26.38 +/- 11.89 years. The most common cause of injury was motor vehicle accident (MVA). Associated head and maxillofacial injury were reported 43.48 and 34.78 per cent, respectively. Before treatment, no light perception was detected in 19.05 per cent of the participants. Treatments were randomized: ten patients received dexamethasone intravenously for 72 hours and 11 methylprednisolone. The best corrected visual acuities (BCVA) were determined using the Snellen Chart before and 1, 2, 3, 7, 14 and 60 days after treatment. Three or more lines of improvement of the BCVA, were found in 70 and 67 per cent of patients treated with dexamethasone, and 45.45 and 33.33 per cent of patients treated with methylprednisolone, at 2 weeks and 2 months, respectively. There were no significant differences in age, cause of injury, injury to treatment interval, initial BCVA and visual improvement between the two groups.
进行了一项随机双盲研究，以比较地塞米松和甲泼尼龙治疗间接性外伤性视神经病变的疗效。21例患者，20例男性和1例女性，被诊断为患有间接性外伤性视神经病变。从受伤到治疗的时间在7天内。平均年龄为26.38±11.89岁。最常见的受伤原因是机动车事故（MVA）。分别有43.48%和34.78%的患者报告伴有头部和颌面损伤。治疗前，19.05%的参与者无光感。治疗随机分组：10例患者静脉注射地塞米松72小时，11例患者静脉注射甲泼尼龙。在治疗前以及治疗后1、2、3、7、14和60天，使用斯内伦视力表测定最佳矫正视力（BCVA）。在治疗2周和2个月时，接受地塞米松治疗的患者中，分别有70%和67%的患者BCVA提高了3行或更多行；接受甲泼尼龙治疗的患者中，这一比例分别为45.45%和33.33%。两组在年龄、受伤原因、受伤至治疗间隔、初始BCVA和视力改善方面无显著差异。
