Li H, Zhou B, Shi J, Cheng L, Wen W, Xu G
Department of Otolaryngology, The First Affiliated Hospital, Nanjing Medical University, China.
J Laryngol Otol. 2008 Dec;122(12):1325-9. doi: 10.1017/S0022215108002296. Epub 2008 Apr 28.
Traumatic optic neuropathy can be treated by various methods including steroids and surgical decompression. Endoscopic optic nerve decompression has been suggested to be effective in treating this condition. The aim of this study was to assess the outcome of treating traumatic optic neuropathy with steroids and endoscopic surgical decompression.
Two hundred and thirty-seven patients with traumatic optic neuropathy were treated with steroids; 176 also consented to endoscopic optic nerve decompression.
The total vision improvement rate was 55 per cent in the 176 patients treated with both steroids and endoscopic optic nerve decompression, compared with 51 per cent in the 61 patients treated with steroids alone; this difference was not statistically significant (p > 0.05). Treatment with steroids plus endoscopic optic nerve decompression resulted in a significantly greater vision improvement in patients with gradual vision loss, compared with those with immediate blindness (68 vs 42 per cent, respectively). Early surgery (within one week) was an important prognostic factor for vision recovery, compared with more delayed surgical treatment (associated vision improvement rates were 60 and 31 per cent, respectively).
Endoscopic optic nerve decompression is a minimally invasive, safe and efficient treatment for traumatic optic neuropathy. Used in combination with steroids, it provides effective rescue for some patients suffering visual loss. It should be undertaken as soon as possible.
创伤性视神经病变可通过多种方法治疗,包括使用类固醇和手术减压。有人提出内镜下视神经减压术对治疗这种疾病有效。本研究的目的是评估使用类固醇和内镜手术减压治疗创伤性视神经病变的效果。
237例创伤性视神经病变患者接受了类固醇治疗;其中176例还同意接受内镜下视神经减压术。
176例同时接受类固醇和内镜下视神经减压术治疗的患者,视力总改善率为55%,而仅接受类固醇治疗的61例患者为51%;这一差异无统计学意义(p>0.05)。与立即失明的患者相比,类固醇联合内镜下视神经减压术治疗视力逐渐丧失的患者视力改善明显更大(分别为68%和42%)。与手术治疗延迟的患者相比,早期手术(一周内)是视力恢复的重要预后因素(相关视力改善率分别为60%和31%)。
内镜下视神经减压术是一种治疗创伤性视神经病变的微创、安全且有效的方法。与类固醇联合使用,可为一些视力丧失的患者提供有效的挽救治疗。应尽早进行。