Wood J L, Lakhani K H, Mason I K, Barnett K C
Epidemiology Unit, Animal Health Trust, Newmarket, Suffolk, UK.
Am J Vet Res. 2001 Sep;62(9):1493-9. doi: 10.2460/ajvr.2001.62.1493.
To assess the association between goniodysgenesis, ocular measurements, and glaucoma in Great Danes.
180 Great Danes.
Eye examination and measurements were obtained from 180 Great Danes; for 30 of these dogs, depth of the anterior chamber, vitreal body length, and total depth of the globe were also measured. These data were merged with electronic pedigree information on 43,371 kennel club registered Great Danes. Relationships among goniodysgenesis, ocular measurements, and glaucoma and the heritability of goniodysgenesis were estimated.
The degree of goniodysgenesis was significantly and positively associated with the likelihood of glaucoma. There was a significant association between the degree of goniodysgenesis in offspring and parents. The estimated heritability of the degree of goniodysgenesis was 0.52. The depth of the anterior chamber of the eye was also a good predictor of goniodysgenesis (ie, the dog was almost certain to have glaucoma if the depth was < 3.7 mm). If both parents had goniodysgenesis < 70%, then with 95% confidence, the occurrence of glaucoma in the ensuing offspring would be < 4/1000. This strategy translates to ensuring that the depth of the anterior chamber of the eye is > 3.7 mm for both parents.
The strong and significant correlation among goniodysgenesis, other eye measurements, and glaucoma and the significant heritability of goniodysgenesis suggests that glaucoma may be heritable in Great Danes. If so, glaucoma can be controlled by breeding only from sires and dams with a minimum degree of goniodysgenesis.
评估大丹犬眼前段发育异常、眼测量参数与青光眼之间的关联。
180只大丹犬。
对180只大丹犬进行眼部检查和测量；其中30只犬还测量了前房深度、玻璃体长度和眼球总深度。这些数据与43371只英国养犬俱乐部注册大丹犬的电子系谱信息相结合。估计眼前段发育异常、眼测量参数与青光眼之间的关系以及眼前段发育异常的遗传力。
眼前段发育异常的程度与青光眼的发生可能性呈显著正相关。后代与父母的眼前段发育异常程度之间存在显著关联。眼前段发育异常程度的估计遗传力为0.52。前房深度也是眼前段发育异常的一个良好预测指标（即，如果深度<3.7mm，犬几乎肯定患有青光眼）。如果双亲的眼前段发育异常均<70%，那么在95%的置信度下，随后代青光眼的发生率将<4/1000。该策略意味着确保双亲的前房深度均>3.7mm。
眼前段发育异常、其他眼测量参数与青光眼之间存在强且显著的相关性，以及眼前段发育异常具有显著的遗传力，这表明青光眼在大丹犬中可能具有遗传性。如果是这样，青光眼可以通过只从眼前段发育异常程度最低的公犬和母犬进行繁殖来控制。
