Wilkerson J D, Brooks D L, Derby M, Griffey S M
Laboratory Animal Resource Center, University of California, Medical Research Building II, Box 0564, San Francisco, California 94143-0564, USA.
Contemp Top Lab Anim Sci. 2001 Sep;40(5):31-6.
This study evaluates the efficacy of various treatment methods to eradicate Dentostomella translucida from Mongolian gerbil colonies. The following five treatment methods were instituted in naturally infected groups of 10 gerbils each: topical ivermectin misting, ivermectin-medicated drinking water, piperazine citrate-medicated drinking water, fenbendazole-medicated feed, and a combination of ivermectin-medicated drinking water and fenbendazole-medicated feed. Treatment success was assessed by using weekly fecal flotations, with necropsy examinations performed on fecal-negative gerbils (except those in the misted group) at 5 weeks after the last treatment. Topical ivermectin misting left 40% of gerbils fecal-positive. With piperazine citrate-medicated drinking water, 60% of the gerbils were fecal-positive; the remaining 40% had adult worms in their digestive tract at necropsy. Ivermectin-medicated drinking water caused 80% of the gerbils to be negative on fecal flotation. On necropsy, however, all but one of these gerbils harbored adult pinworms. Treatments with fenbendazole-supplemented feed alone or in combination with ivermectin-treated water resulted in no fecal shedding or evidence of adult pinworms on necropsy examination. Of the five treatments evaluated, only those using fenbendazole-medicated feed (150 ppm) provided a practical and reliable treatment method to eradicate pinworm infections in Mongolian gerbil colonies.
本研究评估了多种治疗方法根除蒙古沙鼠群体中透明齿线虫的效果。对每组10只自然感染的沙鼠群体采用了以下五种治疗方法：局部喷洒伊维菌素、饮用含伊维菌素的水、饮用含枸橼酸哌嗪的水、食用含芬苯达唑的饲料，以及饮用含伊维菌素的水与食用含芬苯达唑的饲料相结合的方法。通过每周进行粪便漂浮检查来评估治疗效果，在最后一次治疗后5周，对粪便检查呈阴性的沙鼠（喷雾组除外）进行尸检。局部喷洒伊维菌素后，40%的沙鼠粪便检查仍为阳性。饮用含枸橼酸哌嗪的水后，60%的沙鼠粪便检查呈阳性；其余40%在尸检时消化道内有成虫。饮用含伊维菌素的水使80%的沙鼠粪便漂浮检查呈阴性。然而，在尸检时，除一只沙鼠外，所有这些沙鼠体内都有成年蛲虫。单独使用含芬苯达唑的饲料或与含伊维菌素的水处理相结合的治疗方法，在尸检时未发现粪便中有虫卵排出或有成虫的迹象。在评估的五种治疗方法中，只有使用含芬苯达唑的饲料（150 ppm）为根除蒙古沙鼠群体中的蛲虫感染提供了一种实用且可靠的治疗方法。
