Aydın Adnan Menderes University Veterinary Faculty, Department of Parasitology, Aydın, Turkey
Aydın Adnan Menderes University Veterinary Faculty, Department of Pharmacology, Aydın Turkey
Turkiye Parazitol Derg. 2021 Mar 2;45(1):17-21. doi: 10.4274/tpd.galenos.2020.6989.
This study aimed to evaluate the efficacy of eprinomectin, moxidectin and fenbendazole for treating infections in naturally infected Mongolian gerbils ().
A total of 28 gerbils were placed in individually numbered cages to determine the individual animal parasite load. Eggs per gram (EPG) counts were used to estimate the efficacy of the drugs. The day before the anthelmintic administration was denoted as day 0, and the EPG counts were determined by the McMaster technique from the stool removed from the cage bottom on days 7, 14, 21 and 28. The animals were assigned to one of four treatment groups according to their day 0 EPG counts. The orally administered drugs in the treatment groups were eprinomectin (15 mg/kg), moxidectin (0.4 mg/kg) and fenbendazole (12 mg/kg) for groups 1-3, respectively. The fourth group served as the control (without any drug administration).
Treatment efficacy was evaluated based on weekly EPG counts. The values decreased to zero in the fenbendazole group at 4 weeks of follow-up after treatment, and no parasite was found in any of the repeated examinations. The eprinomectin and moxidectin groups exhibited a fluctuating EPG state on both individual and group basis.
, which is known as the specific parasite of gerbils, can easily affect other members of the animal colony; thus, the control of its presence in gerbil breeding units is necessary. Therefore, the reported effective drug treatments are important for the fight against the investigated parasitic infection.
本研究旨在评估依普菌素、莫昔克丁和芬苯达唑治疗自然感染蒙古沙鼠（）的疗效。
将 28 只沙鼠置于编号的单独笼中，以确定个体动物的寄生虫负荷。每克虫卵数（EPG）用于估计药物的疗效。驱虫药给药前一天记为第 0 天，通过 McMaster 技术从笼底取出的粪便中检测第 7、14、21 和 28 天的 EPG 计数。根据第 0 天的 EPG 计数，将动物分配到四个治疗组之一。治疗组 1-3 分别口服依普菌素（15mg/kg）、莫昔克丁（0.4mg/kg）和芬苯达唑（12mg/kg），第四组为对照组（未给予任何药物治疗）。
根据每周的 EPG 计数评估治疗效果。在治疗后 4 周的随访中，芬苯达唑组的 EPG 值降至零，且在任何重复检查中均未发现寄生虫。依普菌素和莫昔克丁组在个体和组水平上的 EPG 状态均呈波动状态。
作为沙鼠特有的寄生虫，能够轻易地影响动物群体中的其他成员；因此，在沙鼠繁殖单位中控制其存在是必要的。因此，报告的有效药物治疗对于对抗寄生虫感染至关重要。
