Charache S, Duffy T P, Jander N, Scott J C, Bedine M, Morrell R
Arch Intern Med. 1975 Aug;135(8):1043-7.
Six patients with sickle cell anemia were treated with sodium cyanate (30 mg/kg/day). In four, treatment was stopped because of definite or suspected toxicity, and no improvement was seen in the other two. Most alarming was the sudden development of peripheral motor neuropathy in a patient whose red blood cells contained less than 0.6 mols NCO-/mol of hemoglobin: six months after treatment was stopped, function had not completely returned in this patient. Safe oral dosage regimens may not be effective, but extra-corporeal treatment of sickle cells with cyanate, or other compounds, might circumvent that problem.
六名镰状细胞贫血患者接受了氰酸钠治疗（30毫克/千克/天）。其中四名患者因明确或疑似毒性而停止治疗，另外两名患者未见改善。最令人担忧的是，一名红细胞中NCO-/血红蛋白摩尔数低于0.6的患者突然出现周围运动神经病变：治疗停止六个月后，该患者的功能尚未完全恢复。安全的口服给药方案可能无效，但用氰酸盐或其他化合物对镰状细胞进行体外治疗可能会规避该问题。
