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Lymphatic vessels as targets of tumor therapy?

作者信息

Karpanen T, Alitalo K

机构信息

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute, and Helsinki University Hospital, Helsinki 00014, Finland.

出版信息

J Exp Med. 2001 Sep 17;194(6):F37-42. doi: 10.1084/jem.194.6.f37.

DOI:10.1084/jem.194.6.f37
PMID:11561002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2195960/
Abstract
摘要

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Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages.真皮淋巴管内皮细胞和血管内皮细胞的分离与鉴定揭示了稳定且功能特化的细胞谱系。
J Exp Med. 2001 Sep 17;194(6):797-808. doi: 10.1084/jem.194.6.797.
2
Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma.血管内皮生长因子-C在黑色素瘤中同时诱导淋巴管生成、血管生成和巨噬细胞募集。
Am J Pathol. 2001 Sep;159(3):893-903. doi: 10.1016/S0002-9440(10)61765-8.
3
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.
Clin Exp Metastasis. 2022 Feb;39(1):159-179. doi: 10.1007/s10585-021-10120-z. Epub 2021 Nov 12.
4
The lymphatic system and sentinel lymph nodes: conduit for cancer metastasis.淋巴系统和前哨淋巴结：癌症转移的途径。
Clin Exp Metastasis. 2022 Feb;39(1):139-157. doi: 10.1007/s10585-021-10123-w. Epub 2021 Oct 15.
5
Tumor-Draining Lymph Secretome En Route to the Regional Lymph Node in Breast Cancer Metastasis.乳腺癌转移过程中肿瘤引流淋巴液分泌组向区域淋巴结转移的研究。
Breast Cancer (Dove Med Press). 2020 Mar 25;12:57-67. doi: 10.2147/BCTT.S236168. eCollection 2020.
6
Meningeal lymphatic vessels regulate brain tumor drainage and immunity.脑膜淋巴管调节脑肿瘤引流和免疫。
Cell Res. 2020 Mar;30(3):229-243. doi: 10.1038/s41422-020-0287-8. Epub 2020 Feb 24.
7
Sonic hedgehog selectively promotes lymphangiogenesis after kidney injury through noncanonical pathway. sonic 刺猬通过非经典途径选择性促进肾损伤后的淋巴管生成。
Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F1022-F1033. doi: 10.1152/ajprenal.00077.2019. Epub 2019 Aug 14.
8
Two Birds, One Stone: Double Hits on Tumor Growth and Lymphangiogenesis by Targeting Vascular Endothelial Growth Factor Receptor 3.一石二鸟：双重打击肿瘤生长和淋巴管生成通过靶向血管内皮生长因子受体 3。
Cells. 2019 Mar 21;8(3):270. doi: 10.3390/cells8030270.
9
Effect of High VEGF-C mRNA Expression on Achievement of Complete Remission in Adult Acute Myeloid Leukemia.高VEGF-C mRNA表达对成人急性髓系白血病完全缓解达成情况的影响
Transl Oncol. 2018 Jun;11(3):567-574. doi: 10.1016/j.tranon.2018.02.018. Epub 2018 Mar 12.
10
Lymphangiogenesis guidance by paracrine and pericellular factors.旁分泌和细胞周因素对淋巴管生成的引导作用
Genes Dev. 2017 Aug 15;31(16):1615-1634. doi: 10.1101/gad.303776.117.
分离的淋巴管内皮细胞通过VEGF-C/D受体VEGFR-3传导生长、存活和迁移信号。
EMBO J. 2001 Sep 3;20(17):4762-73. doi: 10.1093/emboj/20.17.4762.
4
N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling.神经细胞黏附分子（N-CAM）通过诱导成纤维细胞生长因子（FGF）受体信号传导来调节肿瘤细胞与基质的黏附。
Nat Cell Biol. 2001 Jul;3(7):650-7. doi: 10.1038/35083041.
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Lack of lymphangiogenesis despite coexpression of VEGF-C and its receptor Flt-4 in uveal melanoma.葡萄膜黑色素瘤中尽管VEGF-C及其受体Flt-4共表达，但仍缺乏淋巴管生成。
Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1422-8.
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Cancer Res. 2001 Mar 1;61(5):1786-90.
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Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium.小鼠LYVE-1是淋巴管内皮细胞中透明质酸的内吞受体。
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Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice.通过血管内皮生长因子受体-3发出信号足以在转基因小鼠中诱导淋巴管生成。
EMBO J. 2001 Mar 15;20(6):1223-31. doi: 10.1093/emboj/20.6.1223.
10
Involvement of chemokine receptors in breast cancer metastasis.趋化因子受体在乳腺癌转移中的作用。
Nature. 2001 Mar 1;410(6824):50-6. doi: 10.1038/35065016.