Gündel H, Wolf A, Xidara V, Busch R, Ceballos-Baumann A O
Department of Psychosomatic Medicine, Klinikum rechts der Isar, Technische Universität München, Langerstrasse 3, 81675 München, Germany.
J Neurol Neurosurg Psychiatry. 2001 Oct;71(4):499-504. doi: 10.1136/jnnp.71.4.499.
To study the prevalence of psychiatric comorbidity assessed by the use of a structured clinical interview in a large, representative sample of patients with spasmodic torticollis (ST) and to test the hypothesis that social phobia would be highly prevalent.
In a consecutive cohort of 116 patients with ST treated with botulinum toxin overall psychiatric comorbidity was studied prospectively with the structured clinical interview (SCID) for DSM-IV axis I disorders. Physical disability and psychosocial variables were also assessed with standardised self rating questionnaires.
41.3% of the subjects met DSM-IV clinical criteria A-G for current social phobia as the primary psychiatric diagnosis. This figure rose to 56% including secondary and tertiary psychiatric diagnosis. There was no correlation between severity of disease (Tsui score, severity of pain, body image dissatisfaction score) and psychiatric comorbidity. The only significant predictor of psychiatric comorbidity was depressive coping behaviour (logistic regression analysis, p < 0.01; OR=10.8). Compared with a representative sample of the general adult population, in the patients with ST the prevalence of clinically relevant social phobia is 10-fold, of mood disorders 2.4-fold, and of lifetime psychiatric comorbidity 2.6-fold increased.
A particularly high prevalence of social phobia was found in the cohort of patients with ST. The finding of a high prevalence of social phobia and depressive coping behaviour as the main predictor of psychiatric comorbidity may make a subgroup of patients with ST particularly amenable to specific psychotherapeutic interventions.
在一大组具有代表性的痉挛性斜颈(ST)患者样本中,研究使用结构化临床访谈评估精神共病的患病率,并检验社交恐惧症患病率高这一假设。
在连续的116例接受肉毒杆菌毒素治疗的ST患者队列中,采用针对DSM-IV轴I障碍的结构化临床访谈(SCID)对总体精神共病进行前瞻性研究。还使用标准化自评问卷评估身体残疾和心理社会变量。
41.3%的受试者符合DSM-IV当前社交恐惧症的临床标准A-G,作为主要精神诊断。包括二级和三级精神诊断时,这一数字升至56%。疾病严重程度(徐氏评分、疼痛严重程度、身体形象不满评分)与精神共病之间无相关性。精神共病的唯一显著预测因素是抑郁应对行为(逻辑回归分析,p<0.01;OR=10.8)。与一般成年人群的代表性样本相比,ST患者中临床相关社交恐惧症的患病率高出10倍,情绪障碍高出2.4倍,终生精神共病高出2.6倍。
在ST患者队列中发现社交恐惧症患病率特别高。社交恐惧症患病率高以及抑郁应对行为作为精神共病的主要预测因素这一发现,可能使一部分ST患者特别适合接受特定的心理治疗干预。