人类尾状核中对多巴胺敏感的腺苷酸环化酶。对正常对照者和精神分裂症患者的一项研究。

Dopamine-sensitive adenylyl cyclase in human caudate nucleus. A study in control subjects and schizophrenic patients.

作者信息

Carenzi A, Gillin J C, Guidotti A, Schwartz M A, Trabucchi M, Wyatt R J

出版信息

Arch Gen Psychiatry. 1975 Aug;32(8):1056-9. doi: 10.1001/archpsyc.1975.01760260120010.

DOI:10.1001/archpsyc.1975.01760260120010

Abstract

Striatal adenylyl cyclase activity from autopsied human brain is selectively stimulated by low concentrations of dopamine. Under the experimental conditions used, norepinephrine was about three times less potent than dopamine. Histamine and serotonin were ineffective. The stimulation by dopamine was competitively inhibited by haloperidol. There was no difference between the basal adenylyl cyclase activity or its level after dopamine stimulation between nine control subjects without a psychiatric history and seven patients with chronic schizophrenia.

摘要

来自尸检人脑的纹状体腺苷酸环化酶活性受到低浓度多巴胺的选择性刺激。在所使用的实验条件下，去甲肾上腺素的效力约为多巴胺的三分之一。组胺和5-羟色胺无效。多巴胺的刺激作用被氟哌啶醇竞争性抑制。在九名无精神病史的对照受试者和七名慢性精神分裂症患者之间，基础腺苷酸环化酶活性或多巴胺刺激后的活性水平没有差异。