Lee A P, Ice R, Blessey R, Sanmarco M E
Circulation. 1979 Dec;60(7):1519-26. doi: 10.1161/01.cir.60.7.1519.
Eighteen patients with coronary heart disease and an ejection fraction of 0.40 or less were entered into an individualized exercise training program. Maximal symptom-limited exercise stress test and cardiac catheterization studies were performed initially and 12--42 months (average 18.5 months) after exercise training. At the time of the follow-up study, the mean functional aerobic impairment (FAI) improved from 32.1 to 23.4% (p less than or equal to 0.01); resting and submaximal heart rates were significantly lower (p less than 0.01 and 0.05, respectively). There was no significant change in the pulmonary artery or left ventricular end-diastolic pressure, cardiac index, stroke index, left ventricular end-diastolic volume or ejection fraction. Exercise training, therefore, can be beneficial even for patients with impaired ventricular function. Increase in physical work capacity was not correlated with improvement of ventricular function; on the other hand, exercise training did not cause deterioration of ventricular function.
18例冠心病患者，射血分数为0.40或更低，进入个体化运动训练项目。最初以及运动训练后12 - 42个月（平均18.5个月）进行了最大症状限制运动应激试验和心导管检查研究。在随访研究时，平均功能性有氧损伤（FAI）从32.1%改善至23.4%（p≤0.01）；静息心率和次最大心率显著降低（分别为p<0.01和0.05）。肺动脉或左心室舒张末期压力、心脏指数、每搏指数、左心室舒张末期容积或射血分数无显著变化。因此，运动训练即使对心室功能受损的患者也可能有益。体力工作能力的增加与心室功能的改善无关；另一方面，运动训练并未导致心室功能恶化。
