9-脱氮嘌呤N7-核苷在寡核苷酸双链体和三链体中的合成及碱基配对特性
Synthesis and base pairing properties of 9-deazapurine N7-nucleosides in oligonucleotide duplexes and triplexes.
作者信息
Leonard P, Wiglenda T, Seela F
机构信息
Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1279-82. doi: 10.1081/NCN-100002536.
PMID:11563003
Abstract
The 9-deazaguanine N7-2'-deoxyribofuranoside (3) as well as the bromo and iodo derivatives 4a,b were synthesized and incorporated in oligonucleotide duplexes and triplexes. Their base pairing properties were investigated and compared with those of the parent purine N7-2'-deoxyribofuanosides.
摘要
合成了9-脱氮鸟嘌呤N7-2'-脱氧核糖呋喃糖苷（3）以及溴代和碘代衍生物4a、b，并将它们掺入寡核苷酸双链体和三链体中。研究了它们的碱基配对性质，并与母体嘌呤N7-2'-脱氧核糖呋喃糖苷的碱基配对性质进行了比较。
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