脱氧核酸胍；嘌呤核苷的合成及其掺入带正电荷的脱氧核酸胍寡核苷酸中。
Deoxynucleic guanidine; synthesis and incorporation of purine nucleosides into positively charged DNG oligonucleotides.
作者信息
Challa Hemavathi, Bruice Thomas C
机构信息
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.
出版信息
Bioorg Med Chem. 2004 Mar 15;12(6):1475-81. doi: 10.1016/j.bmc.2003.12.043.
PMID:15018921
Abstract
The synthesis of purine nucleosides capable of making the guanidinium linkage is described for the first time starting from the corresponding 2'-deoxynucleosides. The positively charged mixed base DNG oligomer containing guanine was synthesized on solid-phase using CPG as support from 3' to 5' direction using the precursor building block nucleosides.
摘要
首次描述了从相应的2'-脱氧核苷开始合成能够形成胍鎓键的嘌呤核苷。使用前体构建块核苷，以CPG为载体，从3'到5'方向在固相上合成了含鸟嘌呤的带正电荷的混合碱基DNG寡聚物。
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