α-亚麻酸的合成与评价
Synthesis and evaluation of alpha-LNA.
作者信息
Christensen N K, Dalskov J K, Nielsen P
机构信息
Department of Chemistry, University of Southern Denmark, 5230 Odense M, Denmark.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):825-8. doi: 10.1081/NCN-100002438.
PMID:11563124
Abstract
Three different synthetic routes to the alpha-configured LNA thymine monomer starting from D-allose or D-arabinose were investigated. The introduction of one or four alpha-LNA monomers into alpha-DNA had a destabilizing effect on the duplexes. However, a fully modified alpha-LNA sequence displayed strong recognition of complementary RNA, but no transition with DNA.
摘要
研究了从D-阿洛糖或D-阿拉伯糖出发合成α构型LNA胸腺嘧啶单体的三种不同路线。将一个或四个α-LNA单体引入α-DNA对双链体有去稳定化作用。然而，一个完全修饰的α-LNA序列对互补RNA有很强的识别能力，但与DNA没有发生转变。
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