Kumar T Santhosh, Ostergaard Michael E, Sharma Pawan K, Nielsen Poul, Wengel Jesper, Hrdlicka Patrick J
Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark.
Bioorg Med Chem Lett. 2009 May 1;19(9):2396-9. doi: 10.1016/j.bmcl.2009.03.079. Epub 2009 Mar 24.
A short synthetic route to the first beta-l-ribo configured locked nucleic acid (LNA), that is, 2'-amino-beta-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2'-amino-beta-l-LNA thymine monomers into alpha-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.
已经从双环核苷1开发出了第一条β - l -核糖构型的锁核酸（LNA），即2'-氨基-β - l - LNA胸腺嘧啶亚磷酰胺6的短合成路线。将2'-氨基-β - l - LNA胸腺嘧啶单体掺入α - DNA链中会导致探针与互补RNA以平行方向形成稳定的双链体。
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