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通过T细胞介导的自身反应性T细胞控制维持免疫自我耐受：对自身免疫和肿瘤免疫的影响。

Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells: implications for autoimmunity and tumor immunity.

作者信息

Sakaguchi S, Takahashi T, Yamazaki S, Kuniyasu Y, Itoh M, Sakaguchi N, Shimizu J

机构信息

Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Shogoin Kawaharacho 53, Sakyo-ku, Kyoto 606-8507, Japan.

出版信息

Microbes Infect. 2001 Sep;3(11):911-8. doi: 10.1016/s1286-4579(01)01452-6.

DOI:10.1016/s1286-4579(01)01452-6
PMID:11564439
Abstract

T-cell-mediated dominant control of self-reactive T cells is one mechanism for maintaining immunologic self tolerance. It also hampers the generation of immunity to autologous tumor cells. Abrogation of the control can evoke potent tumor immunity as well as autoimmunity in normal animals. This common regulatory mechanism for autoimmunity and tumor immunity can be exploited to devise a novel immunotherapy against cancer.

摘要

T细胞介导的对自身反应性T细胞的显性控制是维持免疫自身耐受的一种机制。它也阻碍了对自体肿瘤细胞的免疫生成。消除这种控制可在正常动物中引发强大的肿瘤免疫以及自身免疫。这种自身免疫和肿瘤免疫的共同调节机制可被利用来设计一种新型的癌症免疫疗法。

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