禁食、苯巴比妥或氢化可的松对患肌病叙利亚仓鼠血清肌酸磷酸激酶和醛缩酶活性的影响。

Effect of fasting, phenobarbital, or hydrocortisone on serum creatine-phosphokinase and aldolase activity in myopathic Syrian hamsters.

作者信息

Solymoss B, Jasmin G

出版信息

Proc Soc Exp Biol Med. 1975 Jun;149(2):491-3. doi: 10.3181/00379727-149-38834.

Abstract

The hereditary polymyopathy and cardiomyopathy of inbred Syrian hamsters (UM X 7.1) are associated with a marked elevation of serum creatine phosphokinase (CPK) and aldolase levels. Fasting (overnight) further increases (+100-500%) the serum concentration of these enzymes in myopathic hamsters; however, no such effect is demonstrable in normal hamsters, or in first generation offspring produced by crossbreeding the two strains (myopathic and normal). The changes are reversible, and the enzyme values return to previous levels within 72 hr. Neither phenobarbital nor hydrocortisone prevents the rises, as shown by CPK determinations; on the contrary, hydrocortisone elicits even greater serum enzyme increases.

摘要

近交系叙利亚仓鼠（UM X 7.1）的遗传性多肌病和心肌病与血清肌酸磷酸激酶（CPK）和醛缩酶水平显著升高有关。禁食（过夜）会使患肌病的仓鼠血清中这些酶的浓度进一步升高（升高100 - 500%）；然而，在正常仓鼠或通过将两种品系（患肌病的和正常的）杂交产生的第一代后代中未观察到这种效应。这些变化是可逆的，酶值在72小时内恢复到先前水平。如CPK测定所示，苯巴比妥和氢化可的松均不能阻止酶水平的升高；相反，氢化可的松会使血清酶升高得更明显。