氢化可的松对肌肉疾病血清肌酸激酶活性的影响。

The effect of hydrocortisone on the serum creatine kinase activity of muscles diseases.

作者信息

Cxyzewski K

出版信息

J Neurol. 1977 Nov 1;216(4):283-7. doi: 10.1007/BF00314052.

DOI:10.1007/BF00314052

PMID:72811

Abstract

Intravenous administration of a single dose of hydrocortisone to patients with the Duchenne type of progressive muscular dystrophy, carriers of Duchenne dystrophy gene caused a short-lasting rise of the serum creatine kinase activity. Administration of hydrocortisone also raised the serum CPK activity in some carriers with a primarly normal CPK level. This phenomenon was observed, though to a lower degree, in limb-girdle muscular dystrophy. The serum CPK activity was sometimes increased after hydrocortisone administration in patients with polymyositis and Kugelberg-Welander spinal muscular atrophy. This phenomenon was never observed in the control group or in cases of myotonic dystrophy. The mechanism of this effect of hydrocortisone on the CPK level is still unknown.

摘要

给杜兴型进行性肌营养不良患者、杜兴肌营养不良基因携带者静脉注射单剂量氢化可的松，可使血清肌酸激酶活性出现短暂升高。给一些血清肌酸磷酸激酶（CPK）水平原本正常的携带者注射氢化可的松后，其血清CPK活性也会升高。在肢带型肌营养不良中也观察到了这种现象，不过程度较轻。在多发性肌炎和库格尔贝格 - 韦兰德脊髓性肌萎缩症患者中，注射氢化可的松后血清CPK活性有时也会增加。在对照组或强直性肌营养不良病例中从未观察到这种现象。氢化可的松对CPK水平产生这种影响的机制仍不清楚。

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本文引用的文献

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Neurology. 1975 Dec;25(12):1111-20. doi: 10.1212/wnl.25.12.1111.

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