Luketic V A
Division of Gastroenterology, Medical College of Virginia Commonwealth University, Richmond, Virginia, USA.
Clin Liver Dis. 2001 Aug;5(3):677-707, ix. doi: 10.1016/s1089-3261(05)70188-4.
Each variceal bleed is associated with 20% to 30% risk of dying. Management of portal hypertension after a bleed consists of (1) control of bleeding and (2) prevention of rebleeding. Effective control of bleeding can be achieved either pharmacologically by administering somatostatin or octreotide or endoscopically via sclerotherapy or variceal band ligation. In practice, both pharmacologic and endoscopic therapy are used concomitantly. Rebleeding can be prevented by endoscopic obliteration of varices. In this setting, variceal ligation is the preferred endoscopic modality. B-blockade is as effective as endoscopic therapy and, in combination, the two modalities may be additive.
每次静脉曲张出血都伴有20%至30%的死亡风险。出血后门静脉高压的管理包括:(1)控制出血;(2)预防再出血。通过给予生长抑素或奥曲肽进行药物治疗,或通过硬化疗法或静脉曲张套扎术进行内镜治疗,均可有效控制出血。实际上,药物治疗和内镜治疗通常同时使用。通过内镜下消除静脉曲张可预防再出血。在这种情况下,静脉曲张套扎术是首选的内镜治疗方式。β受体阻滞剂与内镜治疗效果相当,两者联合使用可能具有相加作用。