小鼠肿瘤细胞系单层培养生命历程中对细胞毒性剂敏感性的变化。
Changes in sensitivity to cytotoxic agents occurring during the life history of monolayer cultures of a mouse tumour cell line.
作者信息
Twentyman P R, Bleehen N M
出版信息
Br J Cancer. 1975 Apr;31(4):417-23. doi: 10.1038/bjc.1975.80.
Abstract
Dose-response curves have been obtained for the response of EMT6 mouse tumour cells in vitro to adriamycin, actinomycin D, nitrogen mustard, BCNU and CCNU. The experiments have been carried out with exponentially growing cells and with cells in early and late plateau phase. The results are discussed with particular reference to discrepancies with the results obtained by other workers in similar systems.
摘要
已获得EMT6小鼠肿瘤细胞在体外对阿霉素、放线菌素D、氮芥、卡莫司汀和洛莫司汀反应的剂量反应曲线。实验针对指数生长期细胞以及处于早、晚期平台期的细胞进行。将结合其他研究人员在类似系统中所得结果存在的差异，对这些结果进行讨论。
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