• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Changes in sensitivity to cytotoxic agents occurring during the life history of monolayer cultures of a mouse tumour cell line.小鼠肿瘤细胞系单层培养生命历程中对细胞毒性剂敏感性的变化。
Br J Cancer. 1975 Apr;31(4):417-23. doi: 10.1038/bjc.1975.80.
2
The relationship between tumour geometry and the response of tumour cells to cytotoxic drugs--an in vitro study using EMT6 multicellular spheroids.肿瘤几何形状与肿瘤细胞对细胞毒性药物反应之间的关系——一项使用EMT6多细胞球体的体外研究。
Int J Cancer. 1985 May 15;35(5):675-82. doi: 10.1002/ijc.2910350517.
3
The response of EMT6 tumor spheroids to combined treatment with misonidazole and either nitrogen mustard, adriamycin, or BCNU.EMT6肿瘤球体对米索硝唑与氮芥、阿霉素或卡氮芥联合治疗的反应。
Cancer Clin Trials. 1980 Fall;3(3):253-6.
4
The response to cytotoxic drugs of EMT6 cells treated either as intact or disaggregated spheroids.完整或分散的球体形式处理的EMT6细胞对细胞毒性药物的反应。
Br J Cancer. 1985 Feb;51(2):211-8. doi: 10.1038/bjc.1985.31.
5
The sensitivity to cytotoxic agents of the EMT6 tumor in vivo. Comparative response of lung nodules in rapid expotential growth and of the solid flank tumour.EMT6肿瘤在体内对细胞毒性药物的敏感性。快速指数生长的肺结节和侧腹实体瘤的比较反应。
Br J Cancer. 1976 Mar;33(3):320-8. doi: 10.1038/bjc.1976.46.
6
Comparative chemosensitivity of exponential- versus plateau-phase cells in both in vitro model systems.
Cancer Treat Rep. 1976 Dec;60(12):1719-22.
7
Effects of alkylating agents on the DNA replication of cultured Yoshida sarcoma cells.烷化剂对培养的吉田肉瘤细胞DNA复制的影响。
Chem Biol Interact. 1982 Mar 15;39(2):191-204. doi: 10.1016/0009-2797(82)90121-1.
8
Cell proliferation kinetics and drug sensitivity of exponential and stationary populations of cultured L1210 cells.培养的L1210细胞指数期和平静期群体的细胞增殖动力学及药物敏感性
Cancer Res. 1977 Apr;37(4):1057-63.
9
Preclinical studies and clinical correlation of the effect of alkylating dose.烷化剂量效应的临床前研究与临床相关性
Cancer Res. 1988 Nov 15;48(22):6417-23.
10
Evidence for reinitiation of proliferative activity following alkylation or radiation.烷基化或辐射后增殖活性重新启动的证据。
Int J Radiat Oncol Biol Phys. 1976 Sep-Oct;1(9-10):903-9. doi: 10.1016/0360-3016(76)90115-2.

引用本文的文献

1
Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors.拉罗曲塞联合放疗治疗实体瘤的临床前评估。
Int J Radiat Biol. 2012 Mar;88(3):277-85. doi: 10.3109/09553002.2012.638359. Epub 2011 Dec 20.
2
Kinetic resistance to anticancer agents.抗癌药物的动力学耐药性。
Cytotechnology. 1993;12(1-3):347-56. doi: 10.1007/BF00744672.
3
The clinical value of immunohistochemically demonstrable CEA in breast cancer: a possible method of selecting patients for adjuvant chemotherapy.免疫组化可检测到的癌胚抗原在乳腺癌中的临床价值：一种选择辅助化疗患者的可能方法。
Br J Cancer. 1982 Nov;46(5):757-64. doi: 10.1038/bjc.1982.268.
4
Effect of cell density on intracellular adriamycin concentration and cytotoxicity in exponential and plateau phase EMT6 cells.细胞密度对指数生长期和平稳期EMT6细胞内阿霉素浓度及细胞毒性的影响。
Br J Cancer. 1984 Mar;49(3):301-6. doi: 10.1038/bjc.1984.47.
5
Survival and cell cycle kinetics responses of Chinese hamster ovary cells, and clones of human adenocarcinoma of the stomach and astrocytoma to diaziquone (AZQ) in vitro.中国仓鼠卵巢细胞、人胃腺癌克隆及星形细胞瘤在体外对重氮醌（AZQ）的存活及细胞周期动力学反应。
Invest New Drugs. 1983;1(1):11-9. doi: 10.1007/BF00180187.
6
Clinical pharmacokinetics of oral CCNU (lomustine).口服洛莫司汀（CCNU）的临床药代动力学
Cancer Chemother Pharmacol. 1985;14(2):125-31. doi: 10.1007/BF00434350.
7
The response to cytotoxic drugs of EMT6 cells treated either as intact or disaggregated spheroids.完整或分散的球体形式处理的EMT6细胞对细胞毒性药物的反应。
Br J Cancer. 1985 Feb;51(2):211-8. doi: 10.1038/bjc.1985.31.
8
Enhancement of adriamycin-induced killing after delayed plating of plateau-phase V79-cells.延迟接种处于平台期的V79细胞后阿霉素诱导杀伤作用的增强。
Br J Cancer. 1986 Aug;54(2):245-9. doi: 10.1038/bjc.1986.169.
9
Evidence for induction and repair of potentially lethal damage in plateau-phase V79 cells after exposure to adriamycin. The importance of removal of adriamycin released from the cells during the post-treatment incubation period.阿霉素处理后处于平台期的V79细胞中潜在致死性损伤的诱导与修复证据。后处理孵育期细胞释放的阿霉素清除的重要性。
Br J Cancer. 1987 Apr;55(4):381-4. doi: 10.1038/bjc.1987.76.
10
Cytokinetic factors in drug resistance of Lewis lung carcinoma: comparison of cells freshly isolated from tumours with cells from exponential and plateau-phase cultures.Lewis肺癌耐药中的细胞动力学因素：从肿瘤中新鲜分离的细胞与指数生长期和平稳期培养细胞的比较
Br J Cancer. 1987 Dec;56(6):755-62. doi: 10.1038/bjc.1987.284.

本文引用的文献

1
Action of cytotoxic agents on the erythroid system of the mouse.细胞毒性药物对小鼠红细胞系统的作用。
J Natl Cancer Inst. 1970 Jan;44(1):117-23.
2
Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo.正常造血及移植淋巴瘤集落形成细胞对体内给予的化疗药物敏感性的比较。
J Natl Cancer Inst. 1966 Aug;37(2):233-45.
3
Sensitivity of confluent and cycling embryonic hamster cells to sulfur mustard, 1,3-bis(2-chloroethyl)-1-nitrosourea, and actinomycin D.
J Natl Cancer Inst. 1969 Mar;42(3):363-8.
4
Factors determining cell killing by chemotherapeutic agents in vivo. II. Melphalan, chlorambucil and nitrogen mustard.体内化疗药物导致细胞杀伤的决定因素。II. 美法仑、苯丁酸氮芥和氮芥
Eur J Cancer (1965). 1971 Feb;7(1):11-6. doi: 10.1016/0014-2964(71)90089-2.
5
Survival responses of dividing and nondividing mammalian cells after treatment with hydroxyurea, arabinosylcytosine, or adriamycin.用羟基脲、阿糖胞苷或阿霉素处理后，分裂和不分裂的哺乳动物细胞的存活反应。
Cancer Res. 1974 Jul;34(7):1616-8.
6
Survival kinetics of cultured human lymphoma cells exposed to adriamycin.暴露于阿霉素的培养人淋巴瘤细胞的存活动力学
Cancer Res. 1973 Jun;33(6):1141-5.
7
Plateau-phase cultures of mammalian cells: an in vitro model for human cancer.哺乳动物细胞的平台期培养：一种人类癌症的体外模型。
Curr Top Radiat Res Q. 1972 Jul;8(1):39-43.
8
Cell proliferation and the action of cytotoxic agents on haemopoietic tissue.细胞增殖以及细胞毒性药物对造血组织的作用。
Br J Haematol. 1972 Dec;23(6):751-8. doi: 10.1111/j.1365-2141.1972.tb03489.x.
9
Tumor chemotherapy: efficacy dependent on mode of growth.肿瘤化疗：疗效取决于生长方式。
J Natl Cancer Inst. 1973 Feb;50(2):467-74. doi: 10.1093/jnci/50.2.467.
10
Differential lethal effect of cytotoxic agents on proliferating and nonproliferating lymphoid cells.
Cancer Res. 1973 Jul;33(7):1716-20.

小鼠肿瘤细胞系单层培养生命历程中对细胞毒性剂敏感性的变化。

Changes in sensitivity to cytotoxic agents occurring during the life history of monolayer cultures of a mouse tumour cell line.

作者信息

Twentyman P R, Bleehen N M

出版信息

Br J Cancer. 1975 Apr;31(4):417-23. doi: 10.1038/bjc.1975.80.

DOI:10.1038/bjc.1975.80
PMID:1156523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009450/
Abstract

Dose-response curves have been obtained for the response of EMT6 mouse tumour cells in vitro to adriamycin, actinomycin D, nitrogen mustard, BCNU and CCNU. The experiments have been carried out with exponentially growing cells and with cells in early and late plateau phase. The results are discussed with particular reference to discrepancies with the results obtained by other workers in similar systems.

摘要

已获得EMT6小鼠肿瘤细胞在体外对阿霉素、放线菌素D、氮芥、卡莫司汀和洛莫司汀反应的剂量反应曲线。实验针对指数生长期细胞以及处于早、晚期平台期的细胞进行。将结合其他研究人员在类似系统中所得结果存在的差异，对这些结果进行讨论。