Mironova O P, Zarubina I V, Krivoruchko B I, Smirnov A V
Patol Fiziol Eksp Ter. 2001 Jul-Sep(3):13-6.
Effects of amtizol and trimetazidine (25 mg/kg, i.p., 30 min before and 6, 24, 48 h after the ischemia) on lipid peroxidation in the brain were studied in white rats undergoing occlusion of the common carotid arteries for 90 min, 24 h and 72 h. It was found that administration of the above drugs decreased accumulation of lipid hydroperoxides and malonic dialdehyde, corrected the activity of antioxidant enzymes in the brain after 90 min of ischemia, inhibited activation of lipid peroxidation, elevated the levels of thiol compounds, increased the activity of the glutathione antioxidant system after 24 and 72 h of ischemia.
研究了氨替唑和曲美他嗪（25毫克/千克，腹腔注射，在缺血前30分钟以及缺血后6、24、48小时给药）对经历90分钟、24小时和72小时颈总动脉闭塞的白色大鼠脑内脂质过氧化的影响。结果发现，给予上述药物可减少脂质氢过氧化物和丙二醛的积累，在缺血90分钟后纠正脑内抗氧化酶的活性，抑制脂质过氧化的激活，提高硫醇化合物水平，在缺血24小时和72小时后增加谷胱甘肽抗氧化系统的活性。
