Ponukalina E V, Afanas'eva G A, Chesnokova N P, Kirichuk V F
Patol Fiziol Eksp Ter. 2001 Jul-Sep(3):17-8.
Lipid peroxidation (LPO) and activity of antioxidant system were studied spectrophotometrically in white rats developing pestilential and choleraic intoxication achieved by intraperitoneal injection of plague autolysate of vaccine EB strain in dose equivalent to DL50, cholerain endotoxin in doses DL50 and DL25 as well as combined effect of choleraic endo- and enterotoxins. With progression of the intoxication, the levels of diene conjugates and malonic dialdehyde in blood plasma and erythrocytes rose. LPO activation in plague intoxication arose in high activity of SOD and blood catalase. In choleraic intoxication the activity of the above enzymes progressively lowered.
通过腹腔注射相当于半数致死剂量（DL50）的鼠疫疫苗EB株自溶物、DL50和DL25剂量的霍乱内毒素以及霍乱内毒素和肠毒素的联合作用，使大白鼠发生鼠疫和霍乱中毒，并用分光光度法研究了脂质过氧化（LPO）和抗氧化系统的活性。随着中毒的进展，血浆和红细胞中双烯共轭物和丙二醛的水平升高。鼠疫中毒时LPO的激活发生在超氧化物歧化酶（SOD）和血液过氧化氢酶的高活性状态下。在霍乱中毒时，上述酶的活性逐渐降低。
