过敏性接触性镍皮炎中的淋巴细胞转化试验
Lymphocyte transformation test in allergic contact nickel dermatitis.
作者信息
Gimenez-Camarasa J M, Garcia-Calderon P, Asensio J, De Moragas J M
出版信息
Br J Dermatol. 1975 Jan;92(1):9-15. doi: 10.1111/j.1365-2133.1975.tb03027.x.
Twenty-five patients with clinically proven, patch test positive nickel dermatitis were studied with the lymphocyte transformation test (LTT). Serial dilutions of NiSO4 were present in the lymphocyte culture. None of the controls showed lymphocyte blast transformation. In fourteen patients maximal incorporation of thymidine occurred at the highest dilutions (I:50,000-I:100,000). In eleven patients the highest incorporation occurred at the lower dilutions. The nature of the antigen responsible for the specific reaction remains unknown.
对25例经临床证实斑贴试验呈阳性的镍皮炎患者进行了淋巴细胞转化试验（LTT）研究。淋巴细胞培养中存在系列稀释的硫酸镍。所有对照组均未显示淋巴细胞母细胞转化。14例患者在最高稀释度（1:50,000 - 1:100,000）时胸腺嘧啶核苷掺入量最高。11例患者在较低稀释度时掺入量最高。引起特异性反应的抗原性质尚不清楚。
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